Systematic Mutagenesis of Genes Encoding Predicted Autotransported Proteins of Burkholderia pseudomallei Identifies Factors Mediating Virulence in Mice, Net Intracellular Replication and a Novel Protein Conferring Serum Resistance

Burkholderia pseudomallei is the causative agent of the severe tropical disease melioidosis, which commonly presents as sepsis. The B. pseudomallei K96243 genome encodes eleven predicted autotransporters, a diverse family of secreted and outer membrane proteins often associated with virulence. In a...

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Detalles Bibliográficos
Autores principales: Adler, Natalie R. Lazar, Stevens, Mark P., Dean, Rachel E., Saint, Richard J., Pankhania, Depesh, Prior, Joann L., Atkins, Timothy P., Kessler, Bianca, Nithichanon, Arnone, Lertmemongkolchai, Ganjana, Galyov, Edouard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382181/
https://www.ncbi.nlm.nih.gov/pubmed/25830295
http://dx.doi.org/10.1371/journal.pone.0121271

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