The Placental Protein Syncytin-1 Impairs Antiviral Responses and Exaggerates Inflammatory Responses to Influenza

BACKGROUND: Pregnancy increases susceptibility to influenza. The placenta releases an immunosuppressive endogenous retroviral protein syncytin-1. We hypothesised that exposure of peripheral monocytes (PBMCs) to syncytin-1 would impair responses to H1N1pdm09 influenza. METHODS AND FINDINGS: Recombina...

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Detalles Bibliográficos
Autores principales: Tolosa, Jorge M., Parsons, Kristy S., Hansbro, Philip M., Smith, Roger, Wark, Peter A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382184/
https://www.ncbi.nlm.nih.gov/pubmed/25831059
http://dx.doi.org/10.1371/journal.pone.0118629

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