No Dopamine Cell Loss or Changes in Cytoskeleton Function in Transgenic Mice Expressing Physiological Levels of Wild Type or G2019S Mutant LRRK2 and in Human Fibroblasts

Mutations within the LRRK2 gene have been identified in Parkinson’s disease (PD) patients and have been implicated in the dysfunction of several cellular pathways. Here, we explore how pathogenic mutations and the inhibition of LRRK2 kinase activity affect cytoskeleton dynamics in mouse and human ce...

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Detalles Bibliográficos
Autores principales: Garcia-Miralles, Marta, Coomaraswamy, Janaky, Häbig, Karina, Herzig, Martin C., Funk, Natalja, Gillardon, Frank, Maisel, Martina, Jucker, Mathias, Gasser, Thomas, Galter, Dagmar, Biskup, Saskia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382199/
https://www.ncbi.nlm.nih.gov/pubmed/25830304
http://dx.doi.org/10.1371/journal.pone.0118947

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