Genome Sequence-Independent Identification of RNA Editing Sites

High-throughput RNA sequencing (RNA-Seq) provides single-nucleotide information that makes it a powerful tool for prediction of RNA editome. A new method, GIREMI, predicts RNA editomes (mainly A-to-I editing) accurately and sensitively using a single RNA-Seq data set, which does not require sample-s...

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Detalles Bibliográficos
Autores principales: Zhang, Qing, Xiao, Xinshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382388/
https://www.ncbi.nlm.nih.gov/pubmed/25730491
http://dx.doi.org/10.1038/nmeth.3314
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author Zhang, Qing
Xiao, Xinshu
author_facet Zhang, Qing
Xiao, Xinshu
author_sort Zhang, Qing
collection PubMed
description High-throughput RNA sequencing (RNA-Seq) provides single-nucleotide information that makes it a powerful tool for prediction of RNA editome. A new method, GIREMI, predicts RNA editomes (mainly A-to-I editing) accurately and sensitively using a single RNA-Seq data set, which does not require sample-specific genome sequence data or high sequencing depth. Using GIREMI, we observed prevailing tissue-specificity of RNA editing and interesting evolutionary patterns of editing sites in human population.
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spelling pubmed-43823882015-10-01 Genome Sequence-Independent Identification of RNA Editing Sites Zhang, Qing Xiao, Xinshu Nat Methods Article High-throughput RNA sequencing (RNA-Seq) provides single-nucleotide information that makes it a powerful tool for prediction of RNA editome. A new method, GIREMI, predicts RNA editomes (mainly A-to-I editing) accurately and sensitively using a single RNA-Seq data set, which does not require sample-specific genome sequence data or high sequencing depth. Using GIREMI, we observed prevailing tissue-specificity of RNA editing and interesting evolutionary patterns of editing sites in human population. 2015-03-02 2015-04 /pmc/articles/PMC4382388/ /pubmed/25730491 http://dx.doi.org/10.1038/nmeth.3314 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zhang, Qing
Xiao, Xinshu
Genome Sequence-Independent Identification of RNA Editing Sites
title Genome Sequence-Independent Identification of RNA Editing Sites
title_full Genome Sequence-Independent Identification of RNA Editing Sites
title_fullStr Genome Sequence-Independent Identification of RNA Editing Sites
title_full_unstemmed Genome Sequence-Independent Identification of RNA Editing Sites
title_short Genome Sequence-Independent Identification of RNA Editing Sites
title_sort genome sequence-independent identification of rna editing sites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382388/
https://www.ncbi.nlm.nih.gov/pubmed/25730491
http://dx.doi.org/10.1038/nmeth.3314
work_keys_str_mv AT zhangqing genomesequenceindependentidentificationofrnaeditingsites
AT xiaoxinshu genomesequenceindependentidentificationofrnaeditingsites

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