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Dendritic Cells and Innate Immunity in Kidney Transplantation

This review summarizes emerging concepts related to the roles of dendritic cells and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, dendritic cells have in rejection and reviews their origin and function in the transplanted kid...

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Detalles Bibliográficos
Autores principales: Zhuang, Quan, Lakkis, Fadi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382394/
https://www.ncbi.nlm.nih.gov/pubmed/25629552
http://dx.doi.org/10.1038/ki.2014.430
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author Zhuang, Quan
Lakkis, Fadi G.
author_facet Zhuang, Quan
Lakkis, Fadi G.
author_sort Zhuang, Quan
collection PubMed
description This review summarizes emerging concepts related to the roles of dendritic cells and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, dendritic cells have in rejection and reviews their origin and function in the transplanted kidney. Second, it introduces the novel concept that recognition of allogeneic non-self by host monocytes (referred to here as innate allorecognition) is necessary for initiating rejection by inducing monocyte differentiation into mature, antigen-presenting dendritic cells. Both concepts provide opportunities for preventing rejection by targeting monocytes or dendritic cells.
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spelling pubmed-43823942015-10-01 Dendritic Cells and Innate Immunity in Kidney Transplantation Zhuang, Quan Lakkis, Fadi G. Kidney Int Article This review summarizes emerging concepts related to the roles of dendritic cells and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, dendritic cells have in rejection and reviews their origin and function in the transplanted kidney. Second, it introduces the novel concept that recognition of allogeneic non-self by host monocytes (referred to here as innate allorecognition) is necessary for initiating rejection by inducing monocyte differentiation into mature, antigen-presenting dendritic cells. Both concepts provide opportunities for preventing rejection by targeting monocytes or dendritic cells. 2015-01-28 2015-04 /pmc/articles/PMC4382394/ /pubmed/25629552 http://dx.doi.org/10.1038/ki.2014.430 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zhuang, Quan
Lakkis, Fadi G.
Dendritic Cells and Innate Immunity in Kidney Transplantation
title Dendritic Cells and Innate Immunity in Kidney Transplantation
title_full Dendritic Cells and Innate Immunity in Kidney Transplantation
title_fullStr Dendritic Cells and Innate Immunity in Kidney Transplantation
title_full_unstemmed Dendritic Cells and Innate Immunity in Kidney Transplantation
title_short Dendritic Cells and Innate Immunity in Kidney Transplantation
title_sort dendritic cells and innate immunity in kidney transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382394/
https://www.ncbi.nlm.nih.gov/pubmed/25629552
http://dx.doi.org/10.1038/ki.2014.430
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