Cargando…

Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease

Low serum magnesium has been associated with kidney function decline in persons with diabetes as well as cardiovascular disease in the general population. Since the association of serum magnesium with incident kidney disease in the general population is unknown, we assessed this in 13,226 participan...

Descripción completa

Detalles Bibliográficos
Autores principales: Tin, Adrienne, Grams, Morgan E., Maruthur, Nisa M., Astor, Brad C., Couper, David, Mosley, Thomas H., Selvin, Elizabeth, Coresh, Josef, Linda Kao, Wen Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382401/
https://www.ncbi.nlm.nih.gov/pubmed/25272232
http://dx.doi.org/10.1038/ki.2014.331
_version_ 1782364590883995648
author Tin, Adrienne
Grams, Morgan E.
Maruthur, Nisa M.
Astor, Brad C.
Couper, David
Mosley, Thomas H.
Selvin, Elizabeth
Coresh, Josef
Linda Kao, Wen Hong
author_facet Tin, Adrienne
Grams, Morgan E.
Maruthur, Nisa M.
Astor, Brad C.
Couper, David
Mosley, Thomas H.
Selvin, Elizabeth
Coresh, Josef
Linda Kao, Wen Hong
author_sort Tin, Adrienne
collection PubMed
description Low serum magnesium has been associated with kidney function decline in persons with diabetes as well as cardiovascular disease in the general population. Since the association of serum magnesium with incident kidney disease in the general population is unknown, we assessed this in 13,226 participants (aged 45 to 65) in the Atherosclerosis Risk in Communities study with baseline estimated glomerular filtration rate of at least 60 ml/min/1.73m2 in years 1987–89 and followed through 2010. The risks for incident chronic kidney disease (CKD) and end-stage renal disease (ESRD) associated with baseline total serum magnesium levels were evaluated using Cox regression. There were 1,965 CKD and 208 ESRD events during a median follow-up of 21 years. In adjusted analysis, low serum magnesium levels (0.7mmol/L or less) had significant associations with incident CKD and ESRD compared with the highest quartile with adjusted hazard ratio of 1.58 (95% CI: 1.35–1.87) for CKD and 2.39 (95% CI: 1.61–3.56) for ESRD. These associations remained significant after excluding users of diuretics and across subgroups stratified by hypertension, diabetes, and self-reported race. Thus, in a large sample of middle-aged adults, low total serum magnesium was independently associated with incident CKD and ESRD. Further studies are needed to determine whether modification of serum magnesium levels might alter subsequent incident kidney disease rates.
format Online
Article
Text
id pubmed-4382401
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-43824012015-10-01 Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease Tin, Adrienne Grams, Morgan E. Maruthur, Nisa M. Astor, Brad C. Couper, David Mosley, Thomas H. Selvin, Elizabeth Coresh, Josef Linda Kao, Wen Hong Kidney Int Article Low serum magnesium has been associated with kidney function decline in persons with diabetes as well as cardiovascular disease in the general population. Since the association of serum magnesium with incident kidney disease in the general population is unknown, we assessed this in 13,226 participants (aged 45 to 65) in the Atherosclerosis Risk in Communities study with baseline estimated glomerular filtration rate of at least 60 ml/min/1.73m2 in years 1987–89 and followed through 2010. The risks for incident chronic kidney disease (CKD) and end-stage renal disease (ESRD) associated with baseline total serum magnesium levels were evaluated using Cox regression. There were 1,965 CKD and 208 ESRD events during a median follow-up of 21 years. In adjusted analysis, low serum magnesium levels (0.7mmol/L or less) had significant associations with incident CKD and ESRD compared with the highest quartile with adjusted hazard ratio of 1.58 (95% CI: 1.35–1.87) for CKD and 2.39 (95% CI: 1.61–3.56) for ESRD. These associations remained significant after excluding users of diuretics and across subgroups stratified by hypertension, diabetes, and self-reported race. Thus, in a large sample of middle-aged adults, low total serum magnesium was independently associated with incident CKD and ESRD. Further studies are needed to determine whether modification of serum magnesium levels might alter subsequent incident kidney disease rates. 2014-10-01 2015-04 /pmc/articles/PMC4382401/ /pubmed/25272232 http://dx.doi.org/10.1038/ki.2014.331 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Tin, Adrienne
Grams, Morgan E.
Maruthur, Nisa M.
Astor, Brad C.
Couper, David
Mosley, Thomas H.
Selvin, Elizabeth
Coresh, Josef
Linda Kao, Wen Hong
Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
title Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
title_full Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
title_fullStr Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
title_full_unstemmed Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
title_short Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
title_sort results from the atherosclerosis risk in communities study suggest that low serum magnesium is associated with incident kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382401/
https://www.ncbi.nlm.nih.gov/pubmed/25272232
http://dx.doi.org/10.1038/ki.2014.331
work_keys_str_mv AT tinadrienne resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT gramsmorgane resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT maruthurnisam resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT astorbradc resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT couperdavid resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT mosleythomash resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT selvinelizabeth resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT coreshjosef resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease
AT lindakaowenhong resultsfromtheatherosclerosisriskincommunitiesstudysuggestthatlowserummagnesiumisassociatedwithincidentkidneydisease