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Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
Low serum magnesium has been associated with kidney function decline in persons with diabetes as well as cardiovascular disease in the general population. Since the association of serum magnesium with incident kidney disease in the general population is unknown, we assessed this in 13,226 participan...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382401/ https://www.ncbi.nlm.nih.gov/pubmed/25272232 http://dx.doi.org/10.1038/ki.2014.331 |
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author | Tin, Adrienne Grams, Morgan E. Maruthur, Nisa M. Astor, Brad C. Couper, David Mosley, Thomas H. Selvin, Elizabeth Coresh, Josef Linda Kao, Wen Hong |
author_facet | Tin, Adrienne Grams, Morgan E. Maruthur, Nisa M. Astor, Brad C. Couper, David Mosley, Thomas H. Selvin, Elizabeth Coresh, Josef Linda Kao, Wen Hong |
author_sort | Tin, Adrienne |
collection | PubMed |
description | Low serum magnesium has been associated with kidney function decline in persons with diabetes as well as cardiovascular disease in the general population. Since the association of serum magnesium with incident kidney disease in the general population is unknown, we assessed this in 13,226 participants (aged 45 to 65) in the Atherosclerosis Risk in Communities study with baseline estimated glomerular filtration rate of at least 60 ml/min/1.73m2 in years 1987–89 and followed through 2010. The risks for incident chronic kidney disease (CKD) and end-stage renal disease (ESRD) associated with baseline total serum magnesium levels were evaluated using Cox regression. There were 1,965 CKD and 208 ESRD events during a median follow-up of 21 years. In adjusted analysis, low serum magnesium levels (0.7mmol/L or less) had significant associations with incident CKD and ESRD compared with the highest quartile with adjusted hazard ratio of 1.58 (95% CI: 1.35–1.87) for CKD and 2.39 (95% CI: 1.61–3.56) for ESRD. These associations remained significant after excluding users of diuretics and across subgroups stratified by hypertension, diabetes, and self-reported race. Thus, in a large sample of middle-aged adults, low total serum magnesium was independently associated with incident CKD and ESRD. Further studies are needed to determine whether modification of serum magnesium levels might alter subsequent incident kidney disease rates. |
format | Online Article Text |
id | pubmed-4382401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-43824012015-10-01 Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease Tin, Adrienne Grams, Morgan E. Maruthur, Nisa M. Astor, Brad C. Couper, David Mosley, Thomas H. Selvin, Elizabeth Coresh, Josef Linda Kao, Wen Hong Kidney Int Article Low serum magnesium has been associated with kidney function decline in persons with diabetes as well as cardiovascular disease in the general population. Since the association of serum magnesium with incident kidney disease in the general population is unknown, we assessed this in 13,226 participants (aged 45 to 65) in the Atherosclerosis Risk in Communities study with baseline estimated glomerular filtration rate of at least 60 ml/min/1.73m2 in years 1987–89 and followed through 2010. The risks for incident chronic kidney disease (CKD) and end-stage renal disease (ESRD) associated with baseline total serum magnesium levels were evaluated using Cox regression. There were 1,965 CKD and 208 ESRD events during a median follow-up of 21 years. In adjusted analysis, low serum magnesium levels (0.7mmol/L or less) had significant associations with incident CKD and ESRD compared with the highest quartile with adjusted hazard ratio of 1.58 (95% CI: 1.35–1.87) for CKD and 2.39 (95% CI: 1.61–3.56) for ESRD. These associations remained significant after excluding users of diuretics and across subgroups stratified by hypertension, diabetes, and self-reported race. Thus, in a large sample of middle-aged adults, low total serum magnesium was independently associated with incident CKD and ESRD. Further studies are needed to determine whether modification of serum magnesium levels might alter subsequent incident kidney disease rates. 2014-10-01 2015-04 /pmc/articles/PMC4382401/ /pubmed/25272232 http://dx.doi.org/10.1038/ki.2014.331 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Tin, Adrienne Grams, Morgan E. Maruthur, Nisa M. Astor, Brad C. Couper, David Mosley, Thomas H. Selvin, Elizabeth Coresh, Josef Linda Kao, Wen Hong Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease |
title | Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease |
title_full | Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease |
title_fullStr | Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease |
title_full_unstemmed | Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease |
title_short | Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease |
title_sort | results from the atherosclerosis risk in communities study suggest that low serum magnesium is associated with incident kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382401/ https://www.ncbi.nlm.nih.gov/pubmed/25272232 http://dx.doi.org/10.1038/ki.2014.331 |
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