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Design and evaluation of a peptide-based immunotoxin for breast cancer therapeutics

Immunotoxins are chimeric proteins comprising a specific cellular targeting domain linked to a cytotoxic factor. Here we describe the design and use of a novel, peptide-based immunotoxin that can initiate selective cytotoxicity on ErbB2-positive cells. ErbB2 is a receptor tyrosine kinase that is ove...

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Detalles Bibliográficos
Autores principales:	Weigel, Kelsey J., Shen, Luqun, Thomas, Clayton L., Alber, Daniel, Drapalik, Lauren, Schafer, Zachary T., Lee, Shaun W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382514/ https://www.ncbi.nlm.nih.gov/pubmed/25853036 http://dx.doi.org/10.1016/j.fob.2015.03.005

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