Evaluation of plitidepsin in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofibrosis: results of preclinical studies and a phase II clinical trial

Previous data established that plitidepsin, a cyclic depsipeptide, exerted activity in a mouse model of myelofibrosis (MF). New preclinical experiments reported herein found that low nanomolar plitidepsin concentrations potently inhibited the proliferation of JAK2V617F-mutated cell lines and reduced...

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Detalles Bibliográficos
Autores principales: Pardanani, A, Tefferi, A, Guglielmelli, P, Bogani, C, Bartalucci, N, Rodríguez, J, Extremera, S, Pérez, I, Alfaro, V, Vannucchi, A M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382667/
https://www.ncbi.nlm.nih.gov/pubmed/25768401
http://dx.doi.org/10.1038/bcj.2015.5

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