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Antidepressant-Like Activity of Flunarizine in Modified Tail Suspension Test in Rats

BACKGROUND: Flunarizine, a Ca(2+) channel blocker, crosses blood brain barrier (BBB), antagonizes calcium influx and interferes with neurotransmitter system. Flunarizine 20 mg/kg exhibited significant antidepressant activity in our previous study using forced swim test (FST) in mice, which was contr...

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Detalles Bibliográficos
Autores principales: Shinde, Vinod, Yegnanarayan, Radha, Shah, Priyank, Gupta, Ankush, Pophale, Prachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382763/
https://www.ncbi.nlm.nih.gov/pubmed/25839001
http://dx.doi.org/10.4103/1947-2714.153921