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The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk

BACKGROUND: Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korean reference value on the prevalence of osteoporosis and on the prediction of fr...

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Autores principales: Lee, Sungwha, Choi, Moon-Gi, Yu, Jaemyung, Ryu, Ohk-Hyun, Yoo, Hyung Joon, Ihm, Sung-Hee, Kim, Doo-Man, Hong, Eun-Gyung, Park, Kyutae, Choi, Myungjin, Choi, Hyunhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382837/
https://www.ncbi.nlm.nih.gov/pubmed/25886842
http://dx.doi.org/10.1186/s12891-015-0523-4
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author Lee, Sungwha
Choi, Moon-Gi
Yu, Jaemyung
Ryu, Ohk-Hyun
Yoo, Hyung Joon
Ihm, Sung-Hee
Kim, Doo-Man
Hong, Eun-Gyung
Park, Kyutae
Choi, Myungjin
Choi, Hyunhee
author_facet Lee, Sungwha
Choi, Moon-Gi
Yu, Jaemyung
Ryu, Ohk-Hyun
Yoo, Hyung Joon
Ihm, Sung-Hee
Kim, Doo-Man
Hong, Eun-Gyung
Park, Kyutae
Choi, Myungjin
Choi, Hyunhee
author_sort Lee, Sungwha
collection PubMed
description BACKGROUND: Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korean reference value on the prevalence of osteoporosis and on the prediction of fracture risk. METHODS: We used femoral neck bone mineral density (BMD) data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011. The Korean reference was identified by the mean and standard deviation of men and women aged 20–29 years. We compared the prevalence and the fracture risk assessment tool (FRAX™) probability obtained from the Korean reference and the NHANES III reference. RESULTS: In men, the prevalence of osteoporosis increased when using the Korean men’s reference, and the difference increased up to 9% for those in their 80s. In women, the prevalence increased when using the NHANES III reference, and the difference increased up to 17% for those in their 80s. The reference value also affected the fracture risk probability, and the difference from changing the reference value increased in women and in subjects with more clinical fracture risk factors. In major osteoporotic fractures, the difference of the risk probability was up to 6% in women aged 70–79 years with two clinical risk factors. For femoral neck fractures, the difference was up to 7% in women aged 50–59 years with two clinical risk factors. CONCLUSIONS: We confirmed that the reference value had significant effects on the prevalence of osteoporosis and on the fracture risk probability. The KNHANES 2008–2011 BMD data reflected the characteristics of the Korean BMD status well with regard to data size and study design; therefore, these data can be used as reference values.
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spelling pubmed-43828372015-04-03 The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk Lee, Sungwha Choi, Moon-Gi Yu, Jaemyung Ryu, Ohk-Hyun Yoo, Hyung Joon Ihm, Sung-Hee Kim, Doo-Man Hong, Eun-Gyung Park, Kyutae Choi, Myungjin Choi, Hyunhee BMC Musculoskelet Disord Research Article BACKGROUND: Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korean reference value on the prevalence of osteoporosis and on the prediction of fracture risk. METHODS: We used femoral neck bone mineral density (BMD) data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011. The Korean reference was identified by the mean and standard deviation of men and women aged 20–29 years. We compared the prevalence and the fracture risk assessment tool (FRAX™) probability obtained from the Korean reference and the NHANES III reference. RESULTS: In men, the prevalence of osteoporosis increased when using the Korean men’s reference, and the difference increased up to 9% for those in their 80s. In women, the prevalence increased when using the NHANES III reference, and the difference increased up to 17% for those in their 80s. The reference value also affected the fracture risk probability, and the difference from changing the reference value increased in women and in subjects with more clinical fracture risk factors. In major osteoporotic fractures, the difference of the risk probability was up to 6% in women aged 70–79 years with two clinical risk factors. For femoral neck fractures, the difference was up to 7% in women aged 50–59 years with two clinical risk factors. CONCLUSIONS: We confirmed that the reference value had significant effects on the prevalence of osteoporosis and on the fracture risk probability. The KNHANES 2008–2011 BMD data reflected the characteristics of the Korean BMD status well with regard to data size and study design; therefore, these data can be used as reference values. BioMed Central 2015-03-27 /pmc/articles/PMC4382837/ /pubmed/25886842 http://dx.doi.org/10.1186/s12891-015-0523-4 Text en © Lee et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lee, Sungwha
Choi, Moon-Gi
Yu, Jaemyung
Ryu, Ohk-Hyun
Yoo, Hyung Joon
Ihm, Sung-Hee
Kim, Doo-Man
Hong, Eun-Gyung
Park, Kyutae
Choi, Myungjin
Choi, Hyunhee
The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
title The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
title_full The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
title_fullStr The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
title_full_unstemmed The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
title_short The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
title_sort effects of the korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382837/
https://www.ncbi.nlm.nih.gov/pubmed/25886842
http://dx.doi.org/10.1186/s12891-015-0523-4
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