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The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
BACKGROUND: Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korean reference value on the prevalence of osteoporosis and on the prediction of fr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382837/ https://www.ncbi.nlm.nih.gov/pubmed/25886842 http://dx.doi.org/10.1186/s12891-015-0523-4 |
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author | Lee, Sungwha Choi, Moon-Gi Yu, Jaemyung Ryu, Ohk-Hyun Yoo, Hyung Joon Ihm, Sung-Hee Kim, Doo-Man Hong, Eun-Gyung Park, Kyutae Choi, Myungjin Choi, Hyunhee |
author_facet | Lee, Sungwha Choi, Moon-Gi Yu, Jaemyung Ryu, Ohk-Hyun Yoo, Hyung Joon Ihm, Sung-Hee Kim, Doo-Man Hong, Eun-Gyung Park, Kyutae Choi, Myungjin Choi, Hyunhee |
author_sort | Lee, Sungwha |
collection | PubMed |
description | BACKGROUND: Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korean reference value on the prevalence of osteoporosis and on the prediction of fracture risk. METHODS: We used femoral neck bone mineral density (BMD) data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011. The Korean reference was identified by the mean and standard deviation of men and women aged 20–29 years. We compared the prevalence and the fracture risk assessment tool (FRAX™) probability obtained from the Korean reference and the NHANES III reference. RESULTS: In men, the prevalence of osteoporosis increased when using the Korean men’s reference, and the difference increased up to 9% for those in their 80s. In women, the prevalence increased when using the NHANES III reference, and the difference increased up to 17% for those in their 80s. The reference value also affected the fracture risk probability, and the difference from changing the reference value increased in women and in subjects with more clinical fracture risk factors. In major osteoporotic fractures, the difference of the risk probability was up to 6% in women aged 70–79 years with two clinical risk factors. For femoral neck fractures, the difference was up to 7% in women aged 50–59 years with two clinical risk factors. CONCLUSIONS: We confirmed that the reference value had significant effects on the prevalence of osteoporosis and on the fracture risk probability. The KNHANES 2008–2011 BMD data reflected the characteristics of the Korean BMD status well with regard to data size and study design; therefore, these data can be used as reference values. |
format | Online Article Text |
id | pubmed-4382837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43828372015-04-03 The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk Lee, Sungwha Choi, Moon-Gi Yu, Jaemyung Ryu, Ohk-Hyun Yoo, Hyung Joon Ihm, Sung-Hee Kim, Doo-Man Hong, Eun-Gyung Park, Kyutae Choi, Myungjin Choi, Hyunhee BMC Musculoskelet Disord Research Article BACKGROUND: Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korean reference value on the prevalence of osteoporosis and on the prediction of fracture risk. METHODS: We used femoral neck bone mineral density (BMD) data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011. The Korean reference was identified by the mean and standard deviation of men and women aged 20–29 years. We compared the prevalence and the fracture risk assessment tool (FRAX™) probability obtained from the Korean reference and the NHANES III reference. RESULTS: In men, the prevalence of osteoporosis increased when using the Korean men’s reference, and the difference increased up to 9% for those in their 80s. In women, the prevalence increased when using the NHANES III reference, and the difference increased up to 17% for those in their 80s. The reference value also affected the fracture risk probability, and the difference from changing the reference value increased in women and in subjects with more clinical fracture risk factors. In major osteoporotic fractures, the difference of the risk probability was up to 6% in women aged 70–79 years with two clinical risk factors. For femoral neck fractures, the difference was up to 7% in women aged 50–59 years with two clinical risk factors. CONCLUSIONS: We confirmed that the reference value had significant effects on the prevalence of osteoporosis and on the fracture risk probability. The KNHANES 2008–2011 BMD data reflected the characteristics of the Korean BMD status well with regard to data size and study design; therefore, these data can be used as reference values. BioMed Central 2015-03-27 /pmc/articles/PMC4382837/ /pubmed/25886842 http://dx.doi.org/10.1186/s12891-015-0523-4 Text en © Lee et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lee, Sungwha Choi, Moon-Gi Yu, Jaemyung Ryu, Ohk-Hyun Yoo, Hyung Joon Ihm, Sung-Hee Kim, Doo-Man Hong, Eun-Gyung Park, Kyutae Choi, Myungjin Choi, Hyunhee The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk |
title | The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk |
title_full | The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk |
title_fullStr | The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk |
title_full_unstemmed | The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk |
title_short | The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk |
title_sort | effects of the korean reference value on the prevalence of osteoporosis and the prediction of fracture risk |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382837/ https://www.ncbi.nlm.nih.gov/pubmed/25886842 http://dx.doi.org/10.1186/s12891-015-0523-4 |
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