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Aquaporins as diagnostic and therapeutic targets in cancer: How far we are?
Aquaporins (AQPs) are a family of water channel proteins distributed in various human tissues, responsible for the transport of small solutes such as glycerol, even gas and ions. The expression of AQPs has been found in more than 20 human cancer types and is significantly correlated with the severit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382841/ https://www.ncbi.nlm.nih.gov/pubmed/25886458 http://dx.doi.org/10.1186/s12967-015-0439-7 |
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author | Wang, Jian Feng, Li Zhu, Zhitu Zheng, Minghuan Wang, Diane Chen, Zhihong Sun, Hongzhi |
author_facet | Wang, Jian Feng, Li Zhu, Zhitu Zheng, Minghuan Wang, Diane Chen, Zhihong Sun, Hongzhi |
author_sort | Wang, Jian |
collection | PubMed |
description | Aquaporins (AQPs) are a family of water channel proteins distributed in various human tissues, responsible for the transport of small solutes such as glycerol, even gas and ions. The expression of AQPs has been found in more than 20 human cancer types and is significantly correlated with the severity of histological tumors and prognosis of patients with cancer. More recent evidence showed that AQPs could also play a role in tumor-associated edema, tumor cell proliferation and migration, and tumor angiogenesis in solid and hematological tumors. Inhibitors of AQPs in tumor cells and microvessels have been suggested as new therapeutic strategies. The present review overviews AQPs structures, expression variation among normal tissues and tumors, AQPs functions and roles in the development of cancer with special focuses on lung, colorectal, liver, brain and breast cancers, and potential AQPs-target inhibitors. We call the special attention to consider AQPs important as diagnostic and therapeutic biomarkers. It may be a novel anticancer therapy by the AQPs inhibition. |
format | Online Article Text |
id | pubmed-4382841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43828412015-04-03 Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? Wang, Jian Feng, Li Zhu, Zhitu Zheng, Minghuan Wang, Diane Chen, Zhihong Sun, Hongzhi J Transl Med Review Aquaporins (AQPs) are a family of water channel proteins distributed in various human tissues, responsible for the transport of small solutes such as glycerol, even gas and ions. The expression of AQPs has been found in more than 20 human cancer types and is significantly correlated with the severity of histological tumors and prognosis of patients with cancer. More recent evidence showed that AQPs could also play a role in tumor-associated edema, tumor cell proliferation and migration, and tumor angiogenesis in solid and hematological tumors. Inhibitors of AQPs in tumor cells and microvessels have been suggested as new therapeutic strategies. The present review overviews AQPs structures, expression variation among normal tissues and tumors, AQPs functions and roles in the development of cancer with special focuses on lung, colorectal, liver, brain and breast cancers, and potential AQPs-target inhibitors. We call the special attention to consider AQPs important as diagnostic and therapeutic biomarkers. It may be a novel anticancer therapy by the AQPs inhibition. BioMed Central 2015-03-21 /pmc/articles/PMC4382841/ /pubmed/25886458 http://dx.doi.org/10.1186/s12967-015-0439-7 Text en © Wang et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Wang, Jian Feng, Li Zhu, Zhitu Zheng, Minghuan Wang, Diane Chen, Zhihong Sun, Hongzhi Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? |
title | Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? |
title_full | Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? |
title_fullStr | Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? |
title_full_unstemmed | Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? |
title_short | Aquaporins as diagnostic and therapeutic targets in cancer: How far we are? |
title_sort | aquaporins as diagnostic and therapeutic targets in cancer: how far we are? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382841/ https://www.ncbi.nlm.nih.gov/pubmed/25886458 http://dx.doi.org/10.1186/s12967-015-0439-7 |
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