Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine...

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Detalles Bibliográficos
Autores principales: Ives, Annette, Nomura, Johji, Martinon, Fabio, Roger, Thierry, LeRoy, Didier, Miner, Jeffrey N., Simon, Gregoire, Busso, Nathalie, So, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382995/
https://www.ncbi.nlm.nih.gov/pubmed/25800347
http://dx.doi.org/10.1038/ncomms7555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382995/
https://www.ncbi.nlm.nih.gov/pubmed/25800347
http://dx.doi.org/10.1038/ncomms7555

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