β(1)-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation

INTRODUCTION: Caspase activation and cardiomyocyte apoptosis have been implicated in lipopolysaccharide (LPS)-induced cardiac contractile dysfunction. We have recently demonstrated that β1-adrenoceptor (AR) activation by endogenous norepinephrine contributes to cardiomyocyte apoptosis in endotoxemic...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yiyang, Wang, Yuan, Yang, Duomeng, Yu, Xiaohui, Li, Hongmei, Lv, Xiuxiu, Lu, Daxiang, Wang, Huadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383083/
https://www.ncbi.nlm.nih.gov/pubmed/25887954
http://dx.doi.org/10.1186/s13054-015-0820-1

Ejemplares similares

Ejemplares similares