Cargando…

The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions

Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kong, Wei, Mou, Xiaoyang, Zhang, Na, Zeng, Weiming, Li, Shasha, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383160/
https://www.ncbi.nlm.nih.gov/pubmed/25866779
http://dx.doi.org/10.1155/2015/394260
_version_ 1782364690021613568
author Kong, Wei
Mou, Xiaoyang
Zhang, Na
Zeng, Weiming
Li, Shasha
Yang, Yang
author_facet Kong, Wei
Mou, Xiaoyang
Zhang, Na
Zeng, Weiming
Li, Shasha
Yang, Yang
author_sort Kong, Wei
collection PubMed
description Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD. In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions. Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm. Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks. The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis. In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis.
format Online
Article
Text
id pubmed-4383160
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43831602015-04-12 The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions Kong, Wei Mou, Xiaoyang Zhang, Na Zeng, Weiming Li, Shasha Yang, Yang Biomed Res Int Research Article Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD. In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions. Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm. Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks. The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis. In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis. Hindawi Publishing Corporation 2015 2015-03-19 /pmc/articles/PMC4383160/ /pubmed/25866779 http://dx.doi.org/10.1155/2015/394260 Text en Copyright © 2015 Wei Kong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kong, Wei
Mou, Xiaoyang
Zhang, Na
Zeng, Weiming
Li, Shasha
Yang, Yang
The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions
title The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions
title_full The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions
title_fullStr The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions
title_full_unstemmed The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions
title_short The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions
title_sort construction of common and specific significance subnetworks of alzheimer's disease from multiple brain regions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383160/
https://www.ncbi.nlm.nih.gov/pubmed/25866779
http://dx.doi.org/10.1155/2015/394260
work_keys_str_mv AT kongwei theconstructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT mouxiaoyang theconstructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT zhangna theconstructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT zengweiming theconstructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT lishasha theconstructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT yangyang theconstructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT kongwei constructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT mouxiaoyang constructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT zhangna constructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT zengweiming constructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT lishasha constructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions
AT yangyang constructionofcommonandspecificsignificancesubnetworksofalzheimersdiseasefrommultiplebrainregions