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The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions
Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383160/ https://www.ncbi.nlm.nih.gov/pubmed/25866779 http://dx.doi.org/10.1155/2015/394260 |
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author | Kong, Wei Mou, Xiaoyang Zhang, Na Zeng, Weiming Li, Shasha Yang, Yang |
author_facet | Kong, Wei Mou, Xiaoyang Zhang, Na Zeng, Weiming Li, Shasha Yang, Yang |
author_sort | Kong, Wei |
collection | PubMed |
description | Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD. In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions. Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm. Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks. The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis. In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis. |
format | Online Article Text |
id | pubmed-4383160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43831602015-04-12 The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions Kong, Wei Mou, Xiaoyang Zhang, Na Zeng, Weiming Li, Shasha Yang, Yang Biomed Res Int Research Article Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD. In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions. Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm. Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks. The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis. In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis. Hindawi Publishing Corporation 2015 2015-03-19 /pmc/articles/PMC4383160/ /pubmed/25866779 http://dx.doi.org/10.1155/2015/394260 Text en Copyright © 2015 Wei Kong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kong, Wei Mou, Xiaoyang Zhang, Na Zeng, Weiming Li, Shasha Yang, Yang The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions |
title | The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions |
title_full | The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions |
title_fullStr | The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions |
title_full_unstemmed | The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions |
title_short | The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions |
title_sort | construction of common and specific significance subnetworks of alzheimer's disease from multiple brain regions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383160/ https://www.ncbi.nlm.nih.gov/pubmed/25866779 http://dx.doi.org/10.1155/2015/394260 |
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