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Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383356/ https://www.ncbi.nlm.nih.gov/pubmed/25866775 http://dx.doi.org/10.1155/2015/320941 |
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author | Bhowmik, Arijit Khan, Rajni Ghosh, Mrinal Kanti |
author_facet | Bhowmik, Arijit Khan, Rajni Ghosh, Mrinal Kanti |
author_sort | Bhowmik, Arijit |
collection | PubMed |
description | Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier. |
format | Online Article Text |
id | pubmed-4383356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43833562015-04-12 Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors Bhowmik, Arijit Khan, Rajni Ghosh, Mrinal Kanti Biomed Res Int Review Article Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier. Hindawi Publishing Corporation 2015 2015-03-19 /pmc/articles/PMC4383356/ /pubmed/25866775 http://dx.doi.org/10.1155/2015/320941 Text en Copyright © 2015 Arijit Bhowmik et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bhowmik, Arijit Khan, Rajni Ghosh, Mrinal Kanti Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors |
title | Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors |
title_full | Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors |
title_fullStr | Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors |
title_full_unstemmed | Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors |
title_short | Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors |
title_sort | blood brain barrier: a challenge for effectual therapy of brain tumors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383356/ https://www.ncbi.nlm.nih.gov/pubmed/25866775 http://dx.doi.org/10.1155/2015/320941 |
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