Cargando…

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transp...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhowmik, Arijit, Khan, Rajni, Ghosh, Mrinal Kanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383356/
https://www.ncbi.nlm.nih.gov/pubmed/25866775
http://dx.doi.org/10.1155/2015/320941
_version_ 1782364717100040192
author Bhowmik, Arijit
Khan, Rajni
Ghosh, Mrinal Kanti
author_facet Bhowmik, Arijit
Khan, Rajni
Ghosh, Mrinal Kanti
author_sort Bhowmik, Arijit
collection PubMed
description Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier.
format Online
Article
Text
id pubmed-4383356
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43833562015-04-12 Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors Bhowmik, Arijit Khan, Rajni Ghosh, Mrinal Kanti Biomed Res Int Review Article Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier. Hindawi Publishing Corporation 2015 2015-03-19 /pmc/articles/PMC4383356/ /pubmed/25866775 http://dx.doi.org/10.1155/2015/320941 Text en Copyright © 2015 Arijit Bhowmik et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bhowmik, Arijit
Khan, Rajni
Ghosh, Mrinal Kanti
Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
title Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
title_full Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
title_fullStr Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
title_full_unstemmed Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
title_short Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
title_sort blood brain barrier: a challenge for effectual therapy of brain tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383356/
https://www.ncbi.nlm.nih.gov/pubmed/25866775
http://dx.doi.org/10.1155/2015/320941
work_keys_str_mv AT bhowmikarijit bloodbrainbarrierachallengeforeffectualtherapyofbraintumors
AT khanrajni bloodbrainbarrierachallengeforeffectualtherapyofbraintumors
AT ghoshmrinalkanti bloodbrainbarrierachallengeforeffectualtherapyofbraintumors