Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker

Objective. To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). Methods. sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was...

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Autores principales: Yang, Shouhua, Cheng, Henghui, Huang, Zaiju, Wang, Xiaoling, Wan, Yinglu, Cai, Jing, Wang, Zehua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383360/
https://www.ncbi.nlm.nih.gov/pubmed/25873749
http://dx.doi.org/10.1155/2015/506428
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author Yang, Shouhua
Cheng, Henghui
Huang, Zaiju
Wang, Xiaoling
Wan, Yinglu
Cai, Jing
Wang, Zehua
author_facet Yang, Shouhua
Cheng, Henghui
Huang, Zaiju
Wang, Xiaoling
Wan, Yinglu
Cai, Jing
Wang, Zehua
author_sort Yang, Shouhua
collection PubMed
description Objective. To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). Methods. sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls. Results. Both sNRP-1 and NRP-1 proteins were correlated with stage. sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%. Conclusions. sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN.
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spelling pubmed-43833602015-04-13 Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker Yang, Shouhua Cheng, Henghui Huang, Zaiju Wang, Xiaoling Wan, Yinglu Cai, Jing Wang, Zehua Dis Markers Research Article Objective. To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). Methods. sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls. Results. Both sNRP-1 and NRP-1 proteins were correlated with stage. sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%. Conclusions. sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN. Hindawi Publishing Corporation 2015 2015-03-19 /pmc/articles/PMC4383360/ /pubmed/25873749 http://dx.doi.org/10.1155/2015/506428 Text en Copyright © 2015 Shouhua Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Shouhua
Cheng, Henghui
Huang, Zaiju
Wang, Xiaoling
Wan, Yinglu
Cai, Jing
Wang, Zehua
Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker
title Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker
title_full Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker
title_fullStr Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker
title_full_unstemmed Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker
title_short Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker
title_sort circulating soluble neuropilin-1 in patients with early cervical cancer and cervical intraepithelial neoplasia can be used as a valuable diagnostic biomarker
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383360/
https://www.ncbi.nlm.nih.gov/pubmed/25873749
http://dx.doi.org/10.1155/2015/506428
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