Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus

The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM). A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the prog...

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Detalles Bibliográficos
Autores principales: Tessaro, Fernando H. G., Ayala, Thais S., Martins, Joilson O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383369/
https://www.ncbi.nlm.nih.gov/pubmed/25866794
http://dx.doi.org/10.1155/2015/568408
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author Tessaro, Fernando H. G.
Ayala, Thais S.
Martins, Joilson O.
author_facet Tessaro, Fernando H. G.
Ayala, Thais S.
Martins, Joilson O.
author_sort Tessaro, Fernando H. G.
collection PubMed
description The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM). A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the progression of diabetes complications. Our review presents recent knowledge about eicosanoid synthesis and signaling in DM-related complications, and discusses eicosanoid-related target therapeutics.
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spelling pubmed-43833692015-04-12 Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus Tessaro, Fernando H. G. Ayala, Thais S. Martins, Joilson O. Biomed Res Int Review Article The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM). A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the progression of diabetes complications. Our review presents recent knowledge about eicosanoid synthesis and signaling in DM-related complications, and discusses eicosanoid-related target therapeutics. Hindawi Publishing Corporation 2015 2015-03-19 /pmc/articles/PMC4383369/ /pubmed/25866794 http://dx.doi.org/10.1155/2015/568408 Text en Copyright © 2015 Fernando H. G. Tessaro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tessaro, Fernando H. G.
Ayala, Thais S.
Martins, Joilson O.
Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus
title Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus
title_full Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus
title_fullStr Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus
title_full_unstemmed Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus
title_short Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus
title_sort lipid mediators are critical in resolving inflammation: a review of the emerging roles of eicosanoids in diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383369/
https://www.ncbi.nlm.nih.gov/pubmed/25866794
http://dx.doi.org/10.1155/2015/568408
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