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Expanding our Understanding of Sequence-Function Relationships of Type II Polyketide Biosynthetic Gene Clusters: Bioinformatics-Guided Identification of Frankiamicin A from Frankia sp. EAN1pec
A large and rapidly increasing number of unstudied “orphan” natural product biosynthetic gene clusters are being uncovered in sequenced microbial genomes. An important goal of modern natural products research is to be able to accurately predict natural product structures and biosynthetic pathways fr...
Autores principales: | Ogasawara, Yasushi, Yackley, Benjamin J., Greenberg, Jacob A., Rogelj, Snezna, Melançon, Charles E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383371/ https://www.ncbi.nlm.nih.gov/pubmed/25837682 http://dx.doi.org/10.1371/journal.pone.0121505 |
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