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Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study
BACKGROUND: Understanding the patterns of HCV RNA levels during acute hepatitis C virus (HCV) infection provides insights into immunopathogenesis and is important for vaccine design. This study evaluated patterns of HCV RNA levels and associated factors among individuals with acute infection. METHOD...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383375/ https://www.ncbi.nlm.nih.gov/pubmed/25837807 http://dx.doi.org/10.1371/journal.pone.0122232 |
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author | Hajarizadeh, Behzad Grady, Bart Page, Kimberly Kim, Arthur Y. McGovern, Barbara H. Cox, Andrea L. Rice, Thomas M. Sacks-Davis, Rachel Bruneau, Julie Morris, Meghan Amin, Janaki Schinkel, Janke Applegate, Tanya Maher, Lisa Hellard, Margaret Lloyd, Andrew R. Prins, Maria Dore, Gregory J. Grebely, Jason |
author_facet | Hajarizadeh, Behzad Grady, Bart Page, Kimberly Kim, Arthur Y. McGovern, Barbara H. Cox, Andrea L. Rice, Thomas M. Sacks-Davis, Rachel Bruneau, Julie Morris, Meghan Amin, Janaki Schinkel, Janke Applegate, Tanya Maher, Lisa Hellard, Margaret Lloyd, Andrew R. Prins, Maria Dore, Gregory J. Grebely, Jason |
author_sort | Hajarizadeh, Behzad |
collection | PubMed |
description | BACKGROUND: Understanding the patterns of HCV RNA levels during acute hepatitis C virus (HCV) infection provides insights into immunopathogenesis and is important for vaccine design. This study evaluated patterns of HCV RNA levels and associated factors among individuals with acute infection. METHODS: Data were from an international collaboration of nine prospective cohorts of acute HCV (InC(3) Study). Participants with well-characterized acute HCV infection (detected within three months post-infection and interval between the peak and subsequent HCV RNA levels≤120 days) were categorised by a priori-defined patterns of HCV RNA levels: i) spontaneous clearance, ii) partial viral control with persistence (≥1 log IU/mL decline in HCV RNA levels following peak) and iii) viral plateau with persistence (increase or <1 log IU/mL decline in HCV RNA levels following peak). Factors associated with HCV RNA patterns were assessed using multinomial logistic regression. RESULTS: Among 643 individuals with acute HCV, 162 with well-characterized acute HCV were identified: spontaneous clearance (32%), partial viral control with persistence (27%), and viral plateau with persistence (41%). HCV RNA levels reached a high viraemic phase within two months following infection, with higher levels in the spontaneous clearance and partial viral control groups, compared to the viral plateau group (median: 6.0, 6.2, 5.3 log IU/mL, respectively; P=0.018). In the two groups with persistence, Interferon lambda 3 (IFNL3) CC genotype was independently associated with partial viral control compared to viral plateau (adjusted odds ratio [AOR]: 2.75; 95%CI: 1.08, 7.02). In the two groups with viral control, female sex was independently associated with spontaneous clearance compared to partial viral control (AOR: 2.86; 95%CI: 1.04, 7.83). CONCLUSIONS: Among individuals with acute HCV, a spectrum of HCV RNA patterns is evident. IFNL3 CC genotype is associated with initial viral control, while female sex is associated with ultimate spontaneous clearance. |
format | Online Article Text |
id | pubmed-4383375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43833752015-04-09 Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study Hajarizadeh, Behzad Grady, Bart Page, Kimberly Kim, Arthur Y. McGovern, Barbara H. Cox, Andrea L. Rice, Thomas M. Sacks-Davis, Rachel Bruneau, Julie Morris, Meghan Amin, Janaki Schinkel, Janke Applegate, Tanya Maher, Lisa Hellard, Margaret Lloyd, Andrew R. Prins, Maria Dore, Gregory J. Grebely, Jason PLoS One Research Article BACKGROUND: Understanding the patterns of HCV RNA levels during acute hepatitis C virus (HCV) infection provides insights into immunopathogenesis and is important for vaccine design. This study evaluated patterns of HCV RNA levels and associated factors among individuals with acute infection. METHODS: Data were from an international collaboration of nine prospective cohorts of acute HCV (InC(3) Study). Participants with well-characterized acute HCV infection (detected within three months post-infection and interval between the peak and subsequent HCV RNA levels≤120 days) were categorised by a priori-defined patterns of HCV RNA levels: i) spontaneous clearance, ii) partial viral control with persistence (≥1 log IU/mL decline in HCV RNA levels following peak) and iii) viral plateau with persistence (increase or <1 log IU/mL decline in HCV RNA levels following peak). Factors associated with HCV RNA patterns were assessed using multinomial logistic regression. RESULTS: Among 643 individuals with acute HCV, 162 with well-characterized acute HCV were identified: spontaneous clearance (32%), partial viral control with persistence (27%), and viral plateau with persistence (41%). HCV RNA levels reached a high viraemic phase within two months following infection, with higher levels in the spontaneous clearance and partial viral control groups, compared to the viral plateau group (median: 6.0, 6.2, 5.3 log IU/mL, respectively; P=0.018). In the two groups with persistence, Interferon lambda 3 (IFNL3) CC genotype was independently associated with partial viral control compared to viral plateau (adjusted odds ratio [AOR]: 2.75; 95%CI: 1.08, 7.02). In the two groups with viral control, female sex was independently associated with spontaneous clearance compared to partial viral control (AOR: 2.86; 95%CI: 1.04, 7.83). CONCLUSIONS: Among individuals with acute HCV, a spectrum of HCV RNA patterns is evident. IFNL3 CC genotype is associated with initial viral control, while female sex is associated with ultimate spontaneous clearance. Public Library of Science 2015-04-02 /pmc/articles/PMC4383375/ /pubmed/25837807 http://dx.doi.org/10.1371/journal.pone.0122232 Text en © 2015 Hajarizadeh et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hajarizadeh, Behzad Grady, Bart Page, Kimberly Kim, Arthur Y. McGovern, Barbara H. Cox, Andrea L. Rice, Thomas M. Sacks-Davis, Rachel Bruneau, Julie Morris, Meghan Amin, Janaki Schinkel, Janke Applegate, Tanya Maher, Lisa Hellard, Margaret Lloyd, Andrew R. Prins, Maria Dore, Gregory J. Grebely, Jason Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study |
title | Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study |
title_full | Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study |
title_fullStr | Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study |
title_full_unstemmed | Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study |
title_short | Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC(3) Study |
title_sort | patterns of hepatitis c virus rna levels during acute infection: the inc(3) study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383375/ https://www.ncbi.nlm.nih.gov/pubmed/25837807 http://dx.doi.org/10.1371/journal.pone.0122232 |
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