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Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220)
More than 30% of acute myeloid leukemia (AML) patients possess activating mutations in the receptor tyrosine kinase FMS-like tyrosine kinase 3 or FLT3. A small-molecule inhibitor of FLT3 (known as quizartinib or AC220) that is currently in clinical trials appears promising for the treatment of AML....
Autores principales: | Zorn, Julie A., Wang, Qi, Fujimura, Eric, Barros, Tiago, Kuriyan, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383440/ https://www.ncbi.nlm.nih.gov/pubmed/25837374 http://dx.doi.org/10.1371/journal.pone.0121177 |
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