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Skeleton and Glucose Metabolism: A Bone-Pancreas Loop

Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolera...

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Detalles Bibliográficos
Autores principales: Faienza, Maria Felicia, Luce, Vincenza, Ventura, Annamaria, Colaianni, Graziana, Colucci, Silvia, Cavallo, Luciano, Grano, Maria, Brunetti, Giacomina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383460/
https://www.ncbi.nlm.nih.gov/pubmed/25873957
http://dx.doi.org/10.1155/2015/758148
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author Faienza, Maria Felicia
Luce, Vincenza
Ventura, Annamaria
Colaianni, Graziana
Colucci, Silvia
Cavallo, Luciano
Grano, Maria
Brunetti, Giacomina
author_facet Faienza, Maria Felicia
Luce, Vincenza
Ventura, Annamaria
Colaianni, Graziana
Colucci, Silvia
Cavallo, Luciano
Grano, Maria
Brunetti, Giacomina
author_sort Faienza, Maria Felicia
collection PubMed
description Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine “gland” and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.
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spelling pubmed-43834602015-04-13 Skeleton and Glucose Metabolism: A Bone-Pancreas Loop Faienza, Maria Felicia Luce, Vincenza Ventura, Annamaria Colaianni, Graziana Colucci, Silvia Cavallo, Luciano Grano, Maria Brunetti, Giacomina Int J Endocrinol Review Article Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine “gland” and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism. Hindawi Publishing Corporation 2015 2015-03-19 /pmc/articles/PMC4383460/ /pubmed/25873957 http://dx.doi.org/10.1155/2015/758148 Text en Copyright © 2015 Maria Felicia Faienza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Faienza, Maria Felicia
Luce, Vincenza
Ventura, Annamaria
Colaianni, Graziana
Colucci, Silvia
Cavallo, Luciano
Grano, Maria
Brunetti, Giacomina
Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
title Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
title_full Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
title_fullStr Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
title_full_unstemmed Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
title_short Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
title_sort skeleton and glucose metabolism: a bone-pancreas loop
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383460/
https://www.ncbi.nlm.nih.gov/pubmed/25873957
http://dx.doi.org/10.1155/2015/758148
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