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Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription
Protein quality control is essential for clearing misfolded and aggregated proteins from the cell, and its failure is associated with many neurodegenerative disorders. Here, we identify two genes, ufd-2 and spr-5, that when inactivated, synergistically and robustly suppress neurotoxicity associated...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383508/ https://www.ncbi.nlm.nih.gov/pubmed/25837623 http://dx.doi.org/10.1371/journal.pbio.1002114 |