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Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign
The recent emergence of artemisinin resistance in the Greater Mekong Subregion poses a major threat to the global effort to control malaria. Tracking the spread and evolution of artemisinin-resistant parasites is critical in aiding efforts to contain the spread of resistance. A total of 417 patient...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383523/ https://www.ncbi.nlm.nih.gov/pubmed/25836766 http://dx.doi.org/10.1371/journal.ppat.1004789 |
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author | Talundzic, Eldin Okoth, Sheila Akinyi Congpuong, Kanungnit Plucinski, Mateusz M. Morton, Lindsay Goldman, Ira F. Kachur, Patrick S. Wongsrichanalai, Chansuda Satimai, Wichai Barnwell, John W. Udhayakumar, Venkatachalam |
author_facet | Talundzic, Eldin Okoth, Sheila Akinyi Congpuong, Kanungnit Plucinski, Mateusz M. Morton, Lindsay Goldman, Ira F. Kachur, Patrick S. Wongsrichanalai, Chansuda Satimai, Wichai Barnwell, John W. Udhayakumar, Venkatachalam |
author_sort | Talundzic, Eldin |
collection | PubMed |
description | The recent emergence of artemisinin resistance in the Greater Mekong Subregion poses a major threat to the global effort to control malaria. Tracking the spread and evolution of artemisinin-resistant parasites is critical in aiding efforts to contain the spread of resistance. A total of 417 patient samples from the year 2007, collected during malaria surveillance studies across ten provinces in Thailand, were genotyped for the candidate Plasmodium falciparum molecular marker of artemisinin resistance K13. Parasite genotypes were examined for K13 propeller mutations associated with artemisinin resistance, signatures of positive selection, and for evidence of whether artemisinin-resistant alleles arose independently across Thailand. A total of seven K13 mutant alleles were found (N458Y, R539T, E556D, P574L, R575K, C580Y, S621F). Notably, the R575K and S621F mutations have previously not been reported in Thailand. The most prevalent artemisinin resistance-associated K13 mutation, C580Y, carried two distinct haplotype profiles that were separated based on geography, along the Thai-Cambodia and Thai-Myanmar borders. It appears these two haplotypes may have independent evolutionary origins. In summary, parasites with K13 propeller mutations associated with artemisinin resistance were widely present along the Thai-Cambodia and Thai-Myanmar borders prior to the implementation of the artemisinin resistance containment project in the region. |
format | Online Article Text |
id | pubmed-4383523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43835232015-04-09 Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign Talundzic, Eldin Okoth, Sheila Akinyi Congpuong, Kanungnit Plucinski, Mateusz M. Morton, Lindsay Goldman, Ira F. Kachur, Patrick S. Wongsrichanalai, Chansuda Satimai, Wichai Barnwell, John W. Udhayakumar, Venkatachalam PLoS Pathog Research Article The recent emergence of artemisinin resistance in the Greater Mekong Subregion poses a major threat to the global effort to control malaria. Tracking the spread and evolution of artemisinin-resistant parasites is critical in aiding efforts to contain the spread of resistance. A total of 417 patient samples from the year 2007, collected during malaria surveillance studies across ten provinces in Thailand, were genotyped for the candidate Plasmodium falciparum molecular marker of artemisinin resistance K13. Parasite genotypes were examined for K13 propeller mutations associated with artemisinin resistance, signatures of positive selection, and for evidence of whether artemisinin-resistant alleles arose independently across Thailand. A total of seven K13 mutant alleles were found (N458Y, R539T, E556D, P574L, R575K, C580Y, S621F). Notably, the R575K and S621F mutations have previously not been reported in Thailand. The most prevalent artemisinin resistance-associated K13 mutation, C580Y, carried two distinct haplotype profiles that were separated based on geography, along the Thai-Cambodia and Thai-Myanmar borders. It appears these two haplotypes may have independent evolutionary origins. In summary, parasites with K13 propeller mutations associated with artemisinin resistance were widely present along the Thai-Cambodia and Thai-Myanmar borders prior to the implementation of the artemisinin resistance containment project in the region. Public Library of Science 2015-04-02 /pmc/articles/PMC4383523/ /pubmed/25836766 http://dx.doi.org/10.1371/journal.ppat.1004789 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Talundzic, Eldin Okoth, Sheila Akinyi Congpuong, Kanungnit Plucinski, Mateusz M. Morton, Lindsay Goldman, Ira F. Kachur, Patrick S. Wongsrichanalai, Chansuda Satimai, Wichai Barnwell, John W. Udhayakumar, Venkatachalam Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign |
title | Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign |
title_full | Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign |
title_fullStr | Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign |
title_full_unstemmed | Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign |
title_short | Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign |
title_sort | selection and spread of artemisinin-resistant alleles in thailand prior to the global artemisinin resistance containment campaign |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383523/ https://www.ncbi.nlm.nih.gov/pubmed/25836766 http://dx.doi.org/10.1371/journal.ppat.1004789 |
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