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Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris)
BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. ME...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
NLM-Export
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383575/ https://www.ncbi.nlm.nih.gov/pubmed/25626179 http://dx.doi.org/10.1289/ehp.1408613 |
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author | Pedersen, Marie Mendez, Michelle A. Schoket, Bernadette Godschalk, Roger W. Espinosa, Ana Landström, Anette Villanueva, Cristina M. Merlo, Domenico F. Fthenou, Eleni Gracia-Lavedan, Esther van Schooten, Frederik-J. Hoek, Gerard Brunborg, Gunnar Meltzer, Helle M. Alexander, Jan Nielsen, Jeanette K. Sunyer, Jordi Wright, John Kovács, Katalin de Hoogh, Kees Gutzkow, Kristine B. Hardie, Laura J. Chatzi, Leda Knudsen, Lisbeth E. Anna, Lívia Ketzel, Matthias Haugen, Margaretha Botsivali, Maria Nieuwenhuijsen, Mark J. Cirach, Marta Toledano, Mireille B. Smith, Rachel B. Fleming, Sarah Agramunt, Silvia Kyrtopoulos, Soterios A. Lukács, Viktória Kleinjans, Jos C. Segerbäck, Dan Kogevinas, Manolis |
author_facet | Pedersen, Marie Mendez, Michelle A. Schoket, Bernadette Godschalk, Roger W. Espinosa, Ana Landström, Anette Villanueva, Cristina M. Merlo, Domenico F. Fthenou, Eleni Gracia-Lavedan, Esther van Schooten, Frederik-J. Hoek, Gerard Brunborg, Gunnar Meltzer, Helle M. Alexander, Jan Nielsen, Jeanette K. Sunyer, Jordi Wright, John Kovács, Katalin de Hoogh, Kees Gutzkow, Kristine B. Hardie, Laura J. Chatzi, Leda Knudsen, Lisbeth E. Anna, Lívia Ketzel, Matthias Haugen, Margaretha Botsivali, Maria Nieuwenhuijsen, Mark J. Cirach, Marta Toledano, Mireille B. Smith, Rachel B. Fleming, Sarah Agramunt, Silvia Kyrtopoulos, Soterios A. Lukács, Viktória Kleinjans, Jos C. Segerbäck, Dan Kogevinas, Manolis |
author_sort | Pedersen, Marie |
collection | PubMed |
description | BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006–2010. Cord blood bulky DNA adduct levels were measured by the (32)P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 10(8) nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates. CITATION: Pedersen M, Mendez MA, Schoket B, Godschalk RW, Espinosa A, Landström A, Villanueva CM, Merlo DF, Fthenou E, Gracia-Lavedan E, van Schooten FJ, Hoek G, Brunborg G, Meltzer HM, Alexander J, Nielsen JK, Sunyer J, Wright J, Kovács K, de Hoogh K, Gutzkow KB, Hardie LJ, Chatzi L, Knudsen LE, Anna L, Ketzel M, Haugen M, Botsivali M, Nieuwenhuijsen MJ, Cirach M, Toledano MB, Smith RB, Fleming S, Agramunt S, Kyrtopoulos SA, Lukács V, Kleinjans JC, Segerbäck D, Kogevinas M. 2015. Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother–child study (NewGeneris). Environ Health Perspect 123:374–380; http://dx.doi.org/10.1289/ehp.1408613 |
format | Online Article Text |
id | pubmed-4383575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | NLM-Export |
record_format | MEDLINE/PubMed |
spelling | pubmed-43835752015-04-09 Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris) Pedersen, Marie Mendez, Michelle A. Schoket, Bernadette Godschalk, Roger W. Espinosa, Ana Landström, Anette Villanueva, Cristina M. Merlo, Domenico F. Fthenou, Eleni Gracia-Lavedan, Esther van Schooten, Frederik-J. Hoek, Gerard Brunborg, Gunnar Meltzer, Helle M. Alexander, Jan Nielsen, Jeanette K. Sunyer, Jordi Wright, John Kovács, Katalin de Hoogh, Kees Gutzkow, Kristine B. Hardie, Laura J. Chatzi, Leda Knudsen, Lisbeth E. Anna, Lívia Ketzel, Matthias Haugen, Margaretha Botsivali, Maria Nieuwenhuijsen, Mark J. Cirach, Marta Toledano, Mireille B. Smith, Rachel B. Fleming, Sarah Agramunt, Silvia Kyrtopoulos, Soterios A. Lukács, Viktória Kleinjans, Jos C. Segerbäck, Dan Kogevinas, Manolis Environ Health Perspect Children's Health BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006–2010. Cord blood bulky DNA adduct levels were measured by the (32)P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 10(8) nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates. CITATION: Pedersen M, Mendez MA, Schoket B, Godschalk RW, Espinosa A, Landström A, Villanueva CM, Merlo DF, Fthenou E, Gracia-Lavedan E, van Schooten FJ, Hoek G, Brunborg G, Meltzer HM, Alexander J, Nielsen JK, Sunyer J, Wright J, Kovács K, de Hoogh K, Gutzkow KB, Hardie LJ, Chatzi L, Knudsen LE, Anna L, Ketzel M, Haugen M, Botsivali M, Nieuwenhuijsen MJ, Cirach M, Toledano MB, Smith RB, Fleming S, Agramunt S, Kyrtopoulos SA, Lukács V, Kleinjans JC, Segerbäck D, Kogevinas M. 2015. Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother–child study (NewGeneris). Environ Health Perspect 123:374–380; http://dx.doi.org/10.1289/ehp.1408613 NLM-Export 2015-01-27 2015-04 /pmc/articles/PMC4383575/ /pubmed/25626179 http://dx.doi.org/10.1289/ehp.1408613 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Children's Health Pedersen, Marie Mendez, Michelle A. Schoket, Bernadette Godschalk, Roger W. Espinosa, Ana Landström, Anette Villanueva, Cristina M. Merlo, Domenico F. Fthenou, Eleni Gracia-Lavedan, Esther van Schooten, Frederik-J. Hoek, Gerard Brunborg, Gunnar Meltzer, Helle M. Alexander, Jan Nielsen, Jeanette K. Sunyer, Jordi Wright, John Kovács, Katalin de Hoogh, Kees Gutzkow, Kristine B. Hardie, Laura J. Chatzi, Leda Knudsen, Lisbeth E. Anna, Lívia Ketzel, Matthias Haugen, Margaretha Botsivali, Maria Nieuwenhuijsen, Mark J. Cirach, Marta Toledano, Mireille B. Smith, Rachel B. Fleming, Sarah Agramunt, Silvia Kyrtopoulos, Soterios A. Lukács, Viktória Kleinjans, Jos C. Segerbäck, Dan Kogevinas, Manolis Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris) |
title | Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris) |
title_full | Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris) |
title_fullStr | Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris) |
title_full_unstemmed | Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris) |
title_short | Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother–Child Study (NewGeneris) |
title_sort | environmental, dietary, maternal, and fetal predictors of bulky dna adducts in cord blood: a european mother–child study (newgeneris) |
topic | Children's Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383575/ https://www.ncbi.nlm.nih.gov/pubmed/25626179 http://dx.doi.org/10.1289/ehp.1408613 |
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