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Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms
miRNAs are small, non-coding RNAs that regulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheum...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383612/ https://www.ncbi.nlm.nih.gov/pubmed/25836258 http://dx.doi.org/10.1371/journal.pone.0122055 |
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author | Xu, Hui Ying Wang, Zhang Yang Chen, Jing Feng Wang, Tian Yang Wang, Ling Ling Tang, Li Li Lin, Xian-yang Zhang, Chun-wu Chen, Bi-cheng |
author_facet | Xu, Hui Ying Wang, Zhang Yang Chen, Jing Feng Wang, Tian Yang Wang, Ling Ling Tang, Li Li Lin, Xian-yang Zhang, Chun-wu Chen, Bi-cheng |
author_sort | Xu, Hui Ying |
collection | PubMed |
description | miRNAs are small, non-coding RNAs that regulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheumatoid arthritis (RA) and osteoarthritis. The present study explored the association between ankylosing spondylitis (AS) and two single nucleotide polymorphisms (SNPs), miR-146a rs2910164G>C and miR-499 rs3746444T>C, in a Han Chinese population. A case–control study consisting of 102 subjects with AS and 105 healthy controls was designed. The two miRNA SNPs were identified by direct sequencing. Subsequently, their gene and genotype frequencies were compared with healthy controls. A significant difference was observed in the miR-146a rs2910164G>C SNP. The frequency of the G allele was markedly higher in the AS patients than in the healthy controls (P = 0.005, P(c) = 0.01, OR = 1.787), and the frequency of the GG genotype was higher in AS patients than in controls (P = 0.014, P(c) = 0.042, OR = 2.516). However, no significant association was found between the miR-499 rs3746444T>C variant and susceptibility to AS. This is the first study to address the association between the miR-146a rs2910164G>C and miR-499 rs3746444T>C polymorphisms and AS, and it suggests a potential pathogenic factor for AS. Further studies are needed to validate our findings in a larger series, as well as in other ethnic backgrounds. |
format | Online Article Text |
id | pubmed-4383612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43836122015-04-09 Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms Xu, Hui Ying Wang, Zhang Yang Chen, Jing Feng Wang, Tian Yang Wang, Ling Ling Tang, Li Li Lin, Xian-yang Zhang, Chun-wu Chen, Bi-cheng PLoS One Research Article miRNAs are small, non-coding RNAs that regulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheumatoid arthritis (RA) and osteoarthritis. The present study explored the association between ankylosing spondylitis (AS) and two single nucleotide polymorphisms (SNPs), miR-146a rs2910164G>C and miR-499 rs3746444T>C, in a Han Chinese population. A case–control study consisting of 102 subjects with AS and 105 healthy controls was designed. The two miRNA SNPs were identified by direct sequencing. Subsequently, their gene and genotype frequencies were compared with healthy controls. A significant difference was observed in the miR-146a rs2910164G>C SNP. The frequency of the G allele was markedly higher in the AS patients than in the healthy controls (P = 0.005, P(c) = 0.01, OR = 1.787), and the frequency of the GG genotype was higher in AS patients than in controls (P = 0.014, P(c) = 0.042, OR = 2.516). However, no significant association was found between the miR-499 rs3746444T>C variant and susceptibility to AS. This is the first study to address the association between the miR-146a rs2910164G>C and miR-499 rs3746444T>C polymorphisms and AS, and it suggests a potential pathogenic factor for AS. Further studies are needed to validate our findings in a larger series, as well as in other ethnic backgrounds. Public Library of Science 2015-04-02 /pmc/articles/PMC4383612/ /pubmed/25836258 http://dx.doi.org/10.1371/journal.pone.0122055 Text en © 2015 Xu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Xu, Hui Ying Wang, Zhang Yang Chen, Jing Feng Wang, Tian Yang Wang, Ling Ling Tang, Li Li Lin, Xian-yang Zhang, Chun-wu Chen, Bi-cheng Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms |
title | Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms |
title_full | Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms |
title_fullStr | Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms |
title_full_unstemmed | Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms |
title_short | Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms |
title_sort | association between ankylosing spondylitis and the mir-146a and mir-499 polymorphisms |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383612/ https://www.ncbi.nlm.nih.gov/pubmed/25836258 http://dx.doi.org/10.1371/journal.pone.0122055 |
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