Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (e.g., poliovirus, coxsackievirus, enterovirus-71, rhinovirus). We demonstrate that ITZ inhibits viral RNA replication by targeting oxy...

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Detalles Bibliográficos
Autores principales: Strating, Jeroen R.P.M., van der Linden, Lonneke, Albulescu, Lucian, Bigay, Joëlle, Arita, Minetaro, Delang, Leen, Leyssen, Pieter, van der Schaar, Hilde M., Lanke, Kjerstin H.W., Thibaut, Hendrik Jan, Ulferts, Rachel, Drin, Guillaume, Schlinck, Nina, Wubbolts, Richard W., Sever, Navdar, Head, Sarah A., Liu, Jun O., Beachy, Philip A., De Matteis, Maria A., Shair, Matthew D., Olkkonen, Vesa M., Neyts, Johan, van Kuppeveld, Frank J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383725/
https://www.ncbi.nlm.nih.gov/pubmed/25640182
http://dx.doi.org/10.1016/j.celrep.2014.12.054

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