Cargando…

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na(+)/H(+) exchanger NHE3 dysfunction in human and murine colitis

A dysfunction of the Na(+)/H(+) exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine. We previously reported a strong decrease in the NHERF family member PDZK1 (NHERF3), which binds to NHE3 and regulates its function in a mouse model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeruva, Sunil, Chodisetti, Giriprakash, Luo, Min, Chen, Mingmin, Cinar, Ayhan, Ludolph, Lisa, Lünnemann, Maria, Goldstein, Julia, Singh, Anurag Kumar, Riederer, Brigitte, Bachmann, Oliver, Bleich, Andre, Gereke, Markus, Bruder, Dunja, Hagen, Susan, He, Peijian, Yun, Chris, Seidler, Ursula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2014
Materias:	Molecular and Cellular Mechanisms of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383727/ https://www.ncbi.nlm.nih.gov/pubmed/25271043 http://dx.doi.org/10.1007/s00424-014-1608-x

Ejemplares similares

IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes
por: Luo, Min, et al.
Publicado: (2017)

Downregulation of the NHE3-Binding PDZ-Adaptor Protein PDZK1 Expression during Cytokine-Induced Inflammation in Interleukin-10–Deficient Mice
por: Lenzen, Henrike, et al.
Publicado: (2012)

Na(+)/H(+) exchanger NHE1 and NHE2 have opposite effects on migration velocity in rat gastric surface cells
por: Paehler vor der Nolte, Anja, et al.
Publicado: (2017)

Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO(3)(-) transport and reduces survival in CFTR-deficient mice
por: Liu, Xuemei, et al.
Publicado: (2014)

Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1
por: Birrane, Gabriel, et al.
Publicado: (2013)

The Mu Subunit of Plasmodium falciparum Clathrin-Associated Adaptor Protein 2 Modulates In Vitro Parasite Response to Artemisinin and Quinine
por: Henriques, Gisela, et al.
Publicado: (2015)

Mechanisms of the Regulation of the Intestinal Na(+)/H(+)Exchanger NHE3
por: He, Peijian, et al.
Publicado: (2010)

Endosomal Adaptor Proteins APPL1 and APPL2 Are Novel Activators of β-Catenin/TCF-mediated Transcription
por: Rashid, Sajid, et al.
Publicado: (2009)

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia
por: Guo, Linqi, et al.
Publicado: (2022)

Challenges in Using Cultured Primary Rodent Hepatocytes or Cell Lines to Study Hepatic HDL Receptor SR-BI Regulation by Its Cytoplasmic Adaptor PDZK1
por: Tsukamoto, Kosuke, et al.
Publicado: (2013)

Defective small intestinal anion secretion, dipeptide absorption, and intestinal failure in suckling NBCe1-deficient mice
por: Yu, Qin, et al.
Publicado: (2016)

Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na(+)/H(+) exchanger NHE3 by glucocorticoids
por: He, Peijian, et al.
Publicado: (2011)

The NHE3 Inhibitor Tenapanor Prevents Intestinal Obstructions in CFTR-Deleted Mice
por: Tan, Xinjie, et al.
Publicado: (2022)

Genes for endosomal NHE6 and NHE9 are misregulated in autism brains
por: Schwede, M, et al.
Publicado: (2014)

First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma
por: Tschernig, Thomas, et al.
Publicado: (2015)

Different Vancomycin-Intermediate Staphylococcus aureus Phenotypes Selected from the Same ST100-hVISA Parental Strain
por: Di Gregorio, Sabrina, et al.
Publicado: (2017)

Pilot Screening to Determine Antimicrobial Synergies in a Multidrug-Resistant Bacterial Strain Library
por: Kim, Si-Hyun, et al.
Publicado: (2016)

Genomic Characterization of Nonclonal mcr-1-Positive Multidrug-Resistant Klebsiella pneumoniae from Clinical Samples in Thailand
por: Srijan, Apichai, et al.
Publicado: (2018)

Morphological and Biological Characteristics of Staphylococcus aureus Biofilm Formed in the Presence of Plasma
por: Sato, Ayami, et al.
Publicado: (2019)

Activity of Cefiderocol Against Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Endemic to Medical Centers in New York City
por: Iregui, Alejandro, et al.
Publicado: (2020)

Resistome and a Novel bla(NDM-1)-Harboring Plasmid of an Acinetobacter haemolyticus Strain from a Children's Hospital in Puebla, Mexico
por: Bello-López, Elena, et al.
Publicado: (2019)

Alliance of Efflux Pumps with β-Lactamases in Multidrug-Resistant Klebsiella pneumoniae Isolates
por: Maurya, Navdezda, et al.
Publicado: (2019)

Mechanisms of Reduced Susceptibility to Cefiderocol Among Isolates from the CREDIBLE-CR and APEKS-NP Clinical Trials
por: Nordmann, Patrice, et al.
Publicado: (2022)

Antimicrobial Resistance and Molecular Characterization of Gene Cassettes from Class 1 Integrons in Escherichia coli Strains
por: Li, Wanxiang, et al.
Publicado: (2022)

Escherichia coli ST471 Producing VIM-4 Metallo-β-Lactamase in Colombia
por: Rada, Ana Mercedes, et al.
Publicado: (2022)

Application of a Kinetic Model for Studying the Spatial Spread of COVID-19
por: Aristov, V. V., et al.
Publicado: (2022)

Genetic and Phenotypic Characterization of the First Canadian Case of Ambler Class A Carbapenemase FRI-8
por: Mataseje, Laura F., et al.
Publicado: (2023)

The SR-BI Partner PDZK1 Facilitates Hepatitis C Virus Entry
por: Eyre, Nicholas S., et al.
Publicado: (2010)

The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine
por: Xia, Weiliang, et al.
Publicado: (2013)

The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance
Publicado: (1995)

Complex Formation between NheB and NheC Is Necessary to Induce Cytotoxic Activity by the Three-Component Bacillus cereus Nhe Enterotoxin
por: Heilkenbrinker, Uta, et al.
Publicado: (2013)

Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals
por: Stegemann-Koniszewski, S., et al.
Publicado: (2016)

Structure of the NheA Component of the Nhe Toxin from Bacillus cereus: Implications for Function
por: Ganash, Magdah, et al.
Publicado: (2013)

Increased Susceptibility for Superinfection with Streptococcus pneumoniae during Influenza Virus Infection Is Not Caused by TLR7-Mediated Lymphopenia
por: Stegemann, Sabine, et al.
Publicado: (2009)

The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
por: García-Heredia, José M., et al.
Publicado: (2017)

Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1)
por: Perez, Marco, et al.
Publicado: (2016)

Role of NHE1 in Nociception
por: Torres-López, Jorge Elías, et al.
Publicado: (2013)

Nedd4-2–dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli
por: Jenkin, Kayte A., et al.
Publicado: (2021)

Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1
por: Xie, Jiaheng, et al.
Publicado: (2021)

Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes
por: Sarker, Rafiquel, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_p1jkep5bcsjmt77ov6be3m88b1