Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep

A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this vir...

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Autores principales: TAMURA, Tomokazu, MINE, Junki, TORII, Shiho, FUJIMOTO, Yuri, OKAMATSU, Masatoshi, SAKODA, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2014
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383782/
https://www.ncbi.nlm.nih.gov/pubmed/25391535
http://dx.doi.org/10.1292/jvms.14-0434
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author TAMURA, Tomokazu
MINE, Junki
TORII, Shiho
FUJIMOTO, Yuri
OKAMATSU, Masatoshi
SAKODA, Yoshihiro
author_facet TAMURA, Tomokazu
MINE, Junki
TORII, Shiho
FUJIMOTO, Yuri
OKAMATSU, Masatoshi
SAKODA, Yoshihiro
author_sort TAMURA, Tomokazu
collection PubMed
description A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.
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spelling pubmed-43837822015-04-06 Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep TAMURA, Tomokazu MINE, Junki TORII, Shiho FUJIMOTO, Yuri OKAMATSU, Masatoshi SAKODA, Yoshihiro J Vet Med Sci Virology A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations. The Japanese Society of Veterinary Science 2014-11-13 2015-03 /pmc/articles/PMC4383782/ /pubmed/25391535 http://dx.doi.org/10.1292/jvms.14-0434 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Virology
TAMURA, Tomokazu
MINE, Junki
TORII, Shiho
FUJIMOTO, Yuri
OKAMATSU, Masatoshi
SAKODA, Yoshihiro
Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep
title Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep
title_full Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep
title_fullStr Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep
title_full_unstemmed Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep
title_short Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep
title_sort pathogenicity of border disease virus fnk2012-1 strain isolated from a pig in the natural host, sheep
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383782/
https://www.ncbi.nlm.nih.gov/pubmed/25391535
http://dx.doi.org/10.1292/jvms.14-0434
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