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Genetic analysis of litter size in mice
We performed quantitative trait locus (QTL) mapping analysis for litter size (total number of pups born and/or number of pups born alive) in 255 backcross mice derived from C57BL/6J and RR/Sgn inbred mice. We identified one significant QTL on chromosome 7 and 4 suggestive QTLs on chromosomes 3, 5, 1...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Veterinary Science
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383785/ https://www.ncbi.nlm.nih.gov/pubmed/25428703 http://dx.doi.org/10.1292/jvms.14-0350 |
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author | SUTO, Jun-ichi |
author_facet | SUTO, Jun-ichi |
author_sort | SUTO, Jun-ichi |
collection | PubMed |
description | We performed quantitative trait locus (QTL) mapping analysis for litter size (total number of pups born and/or number of pups born alive) in 255 backcross mice derived from C57BL/6J and RR/Sgn inbred mice. We identified one significant QTL on chromosome 7 and 4 suggestive QTLs on chromosomes 3, 5, 10 and 13. In addition, two suggestive QTLs were identified on chromosomes 1 and 4 for the number of stillbirth. These results suggested that both litter size and number of stillbirth were heritable traits, although they were controlled by distinct genes. The RR allele was associated with reduced litter size and increased stillbirth at all QTLs. Therefore, RR mothers were observed to have reduced prolificacy in this particular genetic cross. |
format | Online Article Text |
id | pubmed-4383785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43837852015-04-06 Genetic analysis of litter size in mice SUTO, Jun-ichi J Vet Med Sci Laboratory Animal Science We performed quantitative trait locus (QTL) mapping analysis for litter size (total number of pups born and/or number of pups born alive) in 255 backcross mice derived from C57BL/6J and RR/Sgn inbred mice. We identified one significant QTL on chromosome 7 and 4 suggestive QTLs on chromosomes 3, 5, 10 and 13. In addition, two suggestive QTLs were identified on chromosomes 1 and 4 for the number of stillbirth. These results suggested that both litter size and number of stillbirth were heritable traits, although they were controlled by distinct genes. The RR allele was associated with reduced litter size and increased stillbirth at all QTLs. Therefore, RR mothers were observed to have reduced prolificacy in this particular genetic cross. The Japanese Society of Veterinary Science 2014-11-26 2015-03 /pmc/articles/PMC4383785/ /pubmed/25428703 http://dx.doi.org/10.1292/jvms.14-0350 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Laboratory Animal Science SUTO, Jun-ichi Genetic analysis of litter size in mice |
title | Genetic analysis of litter size in mice |
title_full | Genetic analysis of litter size in mice |
title_fullStr | Genetic analysis of litter size in mice |
title_full_unstemmed | Genetic analysis of litter size in mice |
title_short | Genetic analysis of litter size in mice |
title_sort | genetic analysis of litter size in mice |
topic | Laboratory Animal Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383785/ https://www.ncbi.nlm.nih.gov/pubmed/25428703 http://dx.doi.org/10.1292/jvms.14-0350 |
work_keys_str_mv | AT sutojunichi geneticanalysisoflittersizeinmice |