Perinatal Asphyxia Leads to PARP-1 Overactivity, p65 Translocation, IL-1β and TNF-α Overexpression, and Apoptotic-Like Cell Death in Mesencephalon of Neonatal Rats: Prevention by Systemic Neonatal Nicotinamide Administration

Perinatal asphyxia (PA) is a leading cause of neuronal damage in newborns, resulting in long-term neurological and cognitive deficits, in part due to impairment of mesostriatal and mesolimbic neurocircuitries. The insult can be as severe as to menace the integrity of the genome, triggering the overa...

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Detalles Bibliográficos
Autores principales: Neira-Peña, T., Rojas-Mancilla, E., Munoz-Vio, V., Perez, R., Gutierrez-Hernandez, M., Bustamante, D., Morales, P., Hermoso, M. A., Gebicke-Haerter, P., Herrera-Marschitz, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383817/
https://www.ncbi.nlm.nih.gov/pubmed/25835215
http://dx.doi.org/10.1007/s12640-015-9517-0

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