Clinicopathologic features of 112 cases with mantle cell lymphoma

OBJECTIVE: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL). METHODS: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test...

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Detalles Bibliográficos
Autores principales: Zhou, Dong-Mei, Chen, Gang, Zheng, Xiong-Wei, Zhu, Wei-Feng, Chen, Bao-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383843/
https://www.ncbi.nlm.nih.gov/pubmed/25859411
http://dx.doi.org/10.7497/j.issn.2095-3941.2015.0007
Descripción
Sumario:OBJECTIVE: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL). METHODS: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis. RESULTS: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases. CONCLUSION: MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.

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