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HOTAIR: an oncogenic long non-coding RNA in different cancers
Long non-coding RNAs (lncRNAs) refer to a group of RNAs that are usually more than 200 nucleotides and are not involved in protein generation. Instead, lncRNAs are involved in different regulatory processes, such as regulation of gene expression. Different lncRNAs exist throughout the genome. LncRNA...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chinese Anti-Cancer Association
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383848/ https://www.ncbi.nlm.nih.gov/pubmed/25859406 http://dx.doi.org/10.7497/j.issn.2095-3941.2015.0006 |
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author | Hajjari, Mohammadreza Salavaty, Abbas |
author_facet | Hajjari, Mohammadreza Salavaty, Abbas |
author_sort | Hajjari, Mohammadreza |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) refer to a group of RNAs that are usually more than 200 nucleotides and are not involved in protein generation. Instead, lncRNAs are involved in different regulatory processes, such as regulation of gene expression. Different lncRNAs exist throughout the genome. LncRNAs are also known for their roles in different human diseases such as cancer. HOTAIR is an lncRNA that plays a role as an oncogenic molecule in different cancer cells, such as breast, gastric, colorectal, and cervical cancer cells. Therefore, HOTAIR expression level is a potential biomarker for diagnostic and therapeutic purposes in several cancers. This RNA takes part in epigenetic regulation of genes and plays an important role in different cellular pathways by interacting with Polycomb Repressive Complex 2 (PRC2). In this review, we describe the molecular function and regulation of HOTAIR and its role in different types of cancers. |
format | Online Article Text |
id | pubmed-4383848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Chinese Anti-Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-43838482015-04-09 HOTAIR: an oncogenic long non-coding RNA in different cancers Hajjari, Mohammadreza Salavaty, Abbas Cancer Biol Med Review Long non-coding RNAs (lncRNAs) refer to a group of RNAs that are usually more than 200 nucleotides and are not involved in protein generation. Instead, lncRNAs are involved in different regulatory processes, such as regulation of gene expression. Different lncRNAs exist throughout the genome. LncRNAs are also known for their roles in different human diseases such as cancer. HOTAIR is an lncRNA that plays a role as an oncogenic molecule in different cancer cells, such as breast, gastric, colorectal, and cervical cancer cells. Therefore, HOTAIR expression level is a potential biomarker for diagnostic and therapeutic purposes in several cancers. This RNA takes part in epigenetic regulation of genes and plays an important role in different cellular pathways by interacting with Polycomb Repressive Complex 2 (PRC2). In this review, we describe the molecular function and regulation of HOTAIR and its role in different types of cancers. Chinese Anti-Cancer Association 2015-03 /pmc/articles/PMC4383848/ /pubmed/25859406 http://dx.doi.org/10.7497/j.issn.2095-3941.2015.0006 Text en 2015 Cancer Biology & Medicine This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Review Hajjari, Mohammadreza Salavaty, Abbas HOTAIR: an oncogenic long non-coding RNA in different cancers |
title | HOTAIR: an oncogenic long non-coding RNA in different cancers |
title_full | HOTAIR: an oncogenic long non-coding RNA in different cancers |
title_fullStr | HOTAIR: an oncogenic long non-coding RNA in different cancers |
title_full_unstemmed | HOTAIR: an oncogenic long non-coding RNA in different cancers |
title_short | HOTAIR: an oncogenic long non-coding RNA in different cancers |
title_sort | hotair: an oncogenic long non-coding rna in different cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383848/ https://www.ncbi.nlm.nih.gov/pubmed/25859406 http://dx.doi.org/10.7497/j.issn.2095-3941.2015.0006 |
work_keys_str_mv | AT hajjarimohammadreza hotairanoncogeniclongnoncodingrnaindifferentcancers AT salavatyabbas hotairanoncogeniclongnoncodingrnaindifferentcancers |