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PubAngioGen: a database and knowledge for angiogenesis and related diseases
Angiogenesis is the process of generating new blood vessels based on existing ones, which is involved in many diseases including cancers, cardiovascular diseases and diabetes mellitus. Recently, great efforts have been made to explore the mechanisms of angiogenesis in various diseases and many angio...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383947/ https://www.ncbi.nlm.nih.gov/pubmed/25392416 http://dx.doi.org/10.1093/nar/gku1139 |
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author | Li, Peng Liu, Yongrui Wang, Huan He, Yuan Wang, Xue He, Yundong Lv, Fang Chen, Huaqing Pang, Xiufeng Liu, Mingyao Shi, Tieliu Yi, Zhengfang |
author_facet | Li, Peng Liu, Yongrui Wang, Huan He, Yuan Wang, Xue He, Yundong Lv, Fang Chen, Huaqing Pang, Xiufeng Liu, Mingyao Shi, Tieliu Yi, Zhengfang |
author_sort | Li, Peng |
collection | PubMed |
description | Angiogenesis is the process of generating new blood vessels based on existing ones, which is involved in many diseases including cancers, cardiovascular diseases and diabetes mellitus. Recently, great efforts have been made to explore the mechanisms of angiogenesis in various diseases and many angiogenic factors have been discovered as therapeutic targets in anti- or pro-angiogenic drug development. However, the resulted information is sparsely distributed and no systematical summarization has been made. In order to integrate these related results and facilitate the researches for the community, we conducted manual text-mining from published literature and built a database named as PubAngioGen (http://www.megabionet.org/aspd/). Our online application displays a comprehensive network for exploring the connection between angiogenesis and diseases at multilevels including protein–protein interaction, drug-target, disease-gene and signaling pathways among various cells and animal models recorded through text-mining. To enlarge the scope of the PubAngioGen application, our database also links to other common resources including STRING, DrugBank and OMIM databases, which will facilitate understanding the underlying molecular mechanisms of angiogenesis and drug development in clinical therapy. |
format | Online Article Text |
id | pubmed-4383947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43839472015-04-08 PubAngioGen: a database and knowledge for angiogenesis and related diseases Li, Peng Liu, Yongrui Wang, Huan He, Yuan Wang, Xue He, Yundong Lv, Fang Chen, Huaqing Pang, Xiufeng Liu, Mingyao Shi, Tieliu Yi, Zhengfang Nucleic Acids Res Database Issue Angiogenesis is the process of generating new blood vessels based on existing ones, which is involved in many diseases including cancers, cardiovascular diseases and diabetes mellitus. Recently, great efforts have been made to explore the mechanisms of angiogenesis in various diseases and many angiogenic factors have been discovered as therapeutic targets in anti- or pro-angiogenic drug development. However, the resulted information is sparsely distributed and no systematical summarization has been made. In order to integrate these related results and facilitate the researches for the community, we conducted manual text-mining from published literature and built a database named as PubAngioGen (http://www.megabionet.org/aspd/). Our online application displays a comprehensive network for exploring the connection between angiogenesis and diseases at multilevels including protein–protein interaction, drug-target, disease-gene and signaling pathways among various cells and animal models recorded through text-mining. To enlarge the scope of the PubAngioGen application, our database also links to other common resources including STRING, DrugBank and OMIM databases, which will facilitate understanding the underlying molecular mechanisms of angiogenesis and drug development in clinical therapy. Oxford University Press 2014-11-11 2015-01-28 /pmc/articles/PMC4383947/ /pubmed/25392416 http://dx.doi.org/10.1093/nar/gku1139 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Database Issue Li, Peng Liu, Yongrui Wang, Huan He, Yuan Wang, Xue He, Yundong Lv, Fang Chen, Huaqing Pang, Xiufeng Liu, Mingyao Shi, Tieliu Yi, Zhengfang PubAngioGen: a database and knowledge for angiogenesis and related diseases |
title | PubAngioGen: a database and knowledge for angiogenesis and related diseases |
title_full | PubAngioGen: a database and knowledge for angiogenesis and related diseases |
title_fullStr | PubAngioGen: a database and knowledge for angiogenesis and related diseases |
title_full_unstemmed | PubAngioGen: a database and knowledge for angiogenesis and related diseases |
title_short | PubAngioGen: a database and knowledge for angiogenesis and related diseases |
title_sort | pubangiogen: a database and knowledge for angiogenesis and related diseases |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383947/ https://www.ncbi.nlm.nih.gov/pubmed/25392416 http://dx.doi.org/10.1093/nar/gku1139 |
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