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LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what genes are regulated by a specific lncRNA remains to be characterized. To assess the effects of the lncRNA on gene expression, an increasing number of r...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383967/ https://www.ncbi.nlm.nih.gov/pubmed/25399422 http://dx.doi.org/10.1093/nar/gku1173 |
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author | Jiang, Qinghua Wang, Jixuan Wu, Xiaoliang Ma, Rui Zhang, Tianjiao Jin, Shuilin Han, Zhijie Tan, Renjie Peng, Jiajie Liu, Guiyou Li, Yu Wang, Yadong |
author_facet | Jiang, Qinghua Wang, Jixuan Wu, Xiaoliang Ma, Rui Zhang, Tianjiao Jin, Shuilin Han, Zhijie Tan, Renjie Peng, Jiajie Liu, Guiyou Li, Yu Wang, Yadong |
author_sort | Jiang, Qinghua |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what genes are regulated by a specific lncRNA remains to be characterized. To assess the effects of the lncRNA on gene expression, an increasing number of researchers profiled the genome-wide or individual gene expression level change after knocking down or overexpressing the lncRNA. Herein, we describe a curated database named LncRNA2Target, which stores lncRNA-to-target genes and is publicly accessible at http://www.lncrna2target.org. A gene was considered as a target of a lncRNA if it is differentially expressed after the lncRNA knockdown or overexpression. LncRNA2Target provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene. Both search types are performed either by browsing a provided catalog of lncRNA names or by inserting lncRNA/target gene IDs/names in a search box. |
format | Online Article Text |
id | pubmed-4383967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43839672015-04-08 LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression Jiang, Qinghua Wang, Jixuan Wu, Xiaoliang Ma, Rui Zhang, Tianjiao Jin, Shuilin Han, Zhijie Tan, Renjie Peng, Jiajie Liu, Guiyou Li, Yu Wang, Yadong Nucleic Acids Res Database Issue Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what genes are regulated by a specific lncRNA remains to be characterized. To assess the effects of the lncRNA on gene expression, an increasing number of researchers profiled the genome-wide or individual gene expression level change after knocking down or overexpressing the lncRNA. Herein, we describe a curated database named LncRNA2Target, which stores lncRNA-to-target genes and is publicly accessible at http://www.lncrna2target.org. A gene was considered as a target of a lncRNA if it is differentially expressed after the lncRNA knockdown or overexpression. LncRNA2Target provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene. Both search types are performed either by browsing a provided catalog of lncRNA names or by inserting lncRNA/target gene IDs/names in a search box. Oxford University Press 2014-11-15 2015-01-28 /pmc/articles/PMC4383967/ /pubmed/25399422 http://dx.doi.org/10.1093/nar/gku1173 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Database Issue Jiang, Qinghua Wang, Jixuan Wu, Xiaoliang Ma, Rui Zhang, Tianjiao Jin, Shuilin Han, Zhijie Tan, Renjie Peng, Jiajie Liu, Guiyou Li, Yu Wang, Yadong LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression |
title | LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression |
title_full | LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression |
title_fullStr | LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression |
title_full_unstemmed | LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression |
title_short | LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression |
title_sort | lncrna2target: a database for differentially expressed genes after lncrna knockdown or overexpression |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383967/ https://www.ncbi.nlm.nih.gov/pubmed/25399422 http://dx.doi.org/10.1093/nar/gku1173 |
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