CATH: comprehensive structural and functional annotations for genome sequences

The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235 000 protein domain structures and includes 25 million domain predictions. This article provides an update on the major developments in the 2 years since the...

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Detalles Bibliográficos
Autores principales: Sillitoe, Ian, Lewis, Tony E., Cuff, Alison, Das, Sayoni, Ashford, Paul, Dawson, Natalie L., Furnham, Nicholas, Laskowski, Roman A., Lee, David, Lees, Jonathan G., Lehtinen, Sonja, Studer, Romain A., Thornton, Janet, Orengo, Christine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Database Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384018/
https://www.ncbi.nlm.nih.gov/pubmed/25348408
http://dx.doi.org/10.1093/nar/gku947
Descripción
Sumario:The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235 000 protein domain structures and includes 25 million domain predictions. This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our ‘current’ putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.

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