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Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells
Immunoglobulins are molecules produced by activated B cells and plasma cells in response to exposure to antigens. Upon antigen exposure, these molecules are secreted allowing the immune system to recognize and effectively respond to a myriad of pathogens. Immunoglobulin or antibody secreting cells a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384109/ https://www.ncbi.nlm.nih.gov/pubmed/25615546 http://dx.doi.org/10.3390/biom5010020 |
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author | Jackson, David A. Elsawa, Sherine F. |
author_facet | Jackson, David A. Elsawa, Sherine F. |
author_sort | Jackson, David A. |
collection | PubMed |
description | Immunoglobulins are molecules produced by activated B cells and plasma cells in response to exposure to antigens. Upon antigen exposure, these molecules are secreted allowing the immune system to recognize and effectively respond to a myriad of pathogens. Immunoglobulin or antibody secreting cells are the mature form of B lymphocytes, which during their development undergo gene rearrangements and selection in the bone marrow ultimately leading to the generation of B cells, each expressing a single antigen-specific receptor/immunoglobulin molecule. Each individual immunoglobulin molecule has an affinity for a unique motif, or epitope, found on a given antigen. When presented with an antigen, activated B cells differentiate into either plasma cells (which secrete large amounts of antibody that is specific for the inducing antigen), or memory B cells (which are long-lived and elicit a stronger and faster response if the host is re-exposed to the same antigen). The secreted form of immunoglobulin, when bound to an antigen, serves as an effector molecule that directs other cells of the immune system to facilitate the neutralization of soluble antigen or the eradication of the antigen-expressing pathogen. This review will focus on the regulation of secreted immunoglobulin by long-lived normal or disease-associated plasma cells. Specifically, the focus will be on signaling and transcriptional events that regulate the development and homeostasis of long-lived immunoglobulin secreting plasma cells. |
format | Online Article Text |
id | pubmed-4384109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43841092015-05-05 Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells Jackson, David A. Elsawa, Sherine F. Biomolecules Review Immunoglobulins are molecules produced by activated B cells and plasma cells in response to exposure to antigens. Upon antigen exposure, these molecules are secreted allowing the immune system to recognize and effectively respond to a myriad of pathogens. Immunoglobulin or antibody secreting cells are the mature form of B lymphocytes, which during their development undergo gene rearrangements and selection in the bone marrow ultimately leading to the generation of B cells, each expressing a single antigen-specific receptor/immunoglobulin molecule. Each individual immunoglobulin molecule has an affinity for a unique motif, or epitope, found on a given antigen. When presented with an antigen, activated B cells differentiate into either plasma cells (which secrete large amounts of antibody that is specific for the inducing antigen), or memory B cells (which are long-lived and elicit a stronger and faster response if the host is re-exposed to the same antigen). The secreted form of immunoglobulin, when bound to an antigen, serves as an effector molecule that directs other cells of the immune system to facilitate the neutralization of soluble antigen or the eradication of the antigen-expressing pathogen. This review will focus on the regulation of secreted immunoglobulin by long-lived normal or disease-associated plasma cells. Specifically, the focus will be on signaling and transcriptional events that regulate the development and homeostasis of long-lived immunoglobulin secreting plasma cells. MDPI 2015-01-21 /pmc/articles/PMC4384109/ /pubmed/25615546 http://dx.doi.org/10.3390/biom5010020 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jackson, David A. Elsawa, Sherine F. Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells |
title | Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells |
title_full | Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells |
title_fullStr | Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells |
title_full_unstemmed | Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells |
title_short | Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells |
title_sort | factors regulating immunoglobulin production by normal and disease-associated plasma cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384109/ https://www.ncbi.nlm.nih.gov/pubmed/25615546 http://dx.doi.org/10.3390/biom5010020 |
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