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Transcriptional Regulation of Chemokine Expression in Ovarian Cancer

The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis o...

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Detalles Bibliográficos
Autores principales: Singha, Bipradeb, Gatla, Himavanth R., Vancurova, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384120/
https://www.ncbi.nlm.nih.gov/pubmed/25790431
http://dx.doi.org/10.3390/biom5010223
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author Singha, Bipradeb
Gatla, Himavanth R.
Vancurova, Ivana
author_facet Singha, Bipradeb
Gatla, Himavanth R.
Vancurova, Ivana
author_sort Singha, Bipradeb
collection PubMed
description The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies.
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spelling pubmed-43841202015-05-05 Transcriptional Regulation of Chemokine Expression in Ovarian Cancer Singha, Bipradeb Gatla, Himavanth R. Vancurova, Ivana Biomolecules Review The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies. MDPI 2015-03-17 /pmc/articles/PMC4384120/ /pubmed/25790431 http://dx.doi.org/10.3390/biom5010223 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Singha, Bipradeb
Gatla, Himavanth R.
Vancurova, Ivana
Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
title Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
title_full Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
title_fullStr Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
title_full_unstemmed Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
title_short Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
title_sort transcriptional regulation of chemokine expression in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384120/
https://www.ncbi.nlm.nih.gov/pubmed/25790431
http://dx.doi.org/10.3390/biom5010223
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