Cargando…
Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis o...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384120/ https://www.ncbi.nlm.nih.gov/pubmed/25790431 http://dx.doi.org/10.3390/biom5010223 |
_version_ | 1782364855524655104 |
---|---|
author | Singha, Bipradeb Gatla, Himavanth R. Vancurova, Ivana |
author_facet | Singha, Bipradeb Gatla, Himavanth R. Vancurova, Ivana |
author_sort | Singha, Bipradeb |
collection | PubMed |
description | The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies. |
format | Online Article Text |
id | pubmed-4384120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43841202015-05-05 Transcriptional Regulation of Chemokine Expression in Ovarian Cancer Singha, Bipradeb Gatla, Himavanth R. Vancurova, Ivana Biomolecules Review The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies. MDPI 2015-03-17 /pmc/articles/PMC4384120/ /pubmed/25790431 http://dx.doi.org/10.3390/biom5010223 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Singha, Bipradeb Gatla, Himavanth R. Vancurova, Ivana Transcriptional Regulation of Chemokine Expression in Ovarian Cancer |
title | Transcriptional Regulation of Chemokine Expression in Ovarian Cancer |
title_full | Transcriptional Regulation of Chemokine Expression in Ovarian Cancer |
title_fullStr | Transcriptional Regulation of Chemokine Expression in Ovarian Cancer |
title_full_unstemmed | Transcriptional Regulation of Chemokine Expression in Ovarian Cancer |
title_short | Transcriptional Regulation of Chemokine Expression in Ovarian Cancer |
title_sort | transcriptional regulation of chemokine expression in ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384120/ https://www.ncbi.nlm.nih.gov/pubmed/25790431 http://dx.doi.org/10.3390/biom5010223 |
work_keys_str_mv | AT singhabipradeb transcriptionalregulationofchemokineexpressioninovariancancer AT gatlahimavanthr transcriptionalregulationofchemokineexpressioninovariancancer AT vancurovaivana transcriptionalregulationofchemokineexpressioninovariancancer |