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De novo malignancy after liver transplantation: a single-center experience of 14 cases
PURPOSE: The aim of this study is to evaluate the incidence of de novo malignancy after liver transplantation (LT) and compare with those among the general Chinese population. METHODS: A total of 466 patients who had a minimum follow-up time of 6 months were enrolled in the study. All data of medica...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Surgical Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384282/ https://www.ncbi.nlm.nih.gov/pubmed/25844357 http://dx.doi.org/10.4174/astr.2015.88.4.222 |
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author | Gao, Peng Ji Gao, Jie Li, Zhao Hu, Zhi Ping Zhu, Ji Ye |
author_facet | Gao, Peng Ji Gao, Jie Li, Zhao Hu, Zhi Ping Zhu, Ji Ye |
author_sort | Gao, Peng Ji |
collection | PubMed |
description | PURPOSE: The aim of this study is to evaluate the incidence of de novo malignancy after liver transplantation (LT) and compare with those among the general Chinese population. METHODS: A total of 466 patients who had a minimum follow-up time of 6 months were enrolled in the study. All data of medical records and follow up were retrospectively reviewed. RESULTS: The incidence rate of de novo malignancy was 3.0% (14 in 466 patients). The median elapsed time from transplant to the diagnosis of de novo malignancy was 42 months (range, 6 to 106 months). The cumulative risk for development of de novo malignancy was 1.6%, 2.7%, and 8.2% at 3, 5 and 10 years after LT, respectively. The patients were all male. The types of de novo tumors included digestive system tumor (8 in 14), lung cancer (2 in 14), urologic neoplasm (2 in 14), and hematologic malignant tumor (2 in 14). Over a mean follow-up of 24 months after diagnosis of de novo malignancy, 7 patients (50.0%) died; the overall 5-year patient survival rate was 54.5%. The relative risk of malignancy following LT was 9.5 folds higher than the general Chinese population. CONCLUSION: The relative risk of malignancy following LT was much higher than the general Chinese population. Digestive system tumor is the most common type of de novo malignancy after LT in China. |
format | Online Article Text |
id | pubmed-4384282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Surgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-43842822015-04-03 De novo malignancy after liver transplantation: a single-center experience of 14 cases Gao, Peng Ji Gao, Jie Li, Zhao Hu, Zhi Ping Zhu, Ji Ye Ann Surg Treat Res Original Article PURPOSE: The aim of this study is to evaluate the incidence of de novo malignancy after liver transplantation (LT) and compare with those among the general Chinese population. METHODS: A total of 466 patients who had a minimum follow-up time of 6 months were enrolled in the study. All data of medical records and follow up were retrospectively reviewed. RESULTS: The incidence rate of de novo malignancy was 3.0% (14 in 466 patients). The median elapsed time from transplant to the diagnosis of de novo malignancy was 42 months (range, 6 to 106 months). The cumulative risk for development of de novo malignancy was 1.6%, 2.7%, and 8.2% at 3, 5 and 10 years after LT, respectively. The patients were all male. The types of de novo tumors included digestive system tumor (8 in 14), lung cancer (2 in 14), urologic neoplasm (2 in 14), and hematologic malignant tumor (2 in 14). Over a mean follow-up of 24 months after diagnosis of de novo malignancy, 7 patients (50.0%) died; the overall 5-year patient survival rate was 54.5%. The relative risk of malignancy following LT was 9.5 folds higher than the general Chinese population. CONCLUSION: The relative risk of malignancy following LT was much higher than the general Chinese population. Digestive system tumor is the most common type of de novo malignancy after LT in China. The Korean Surgical Society 2015-04 2015-03-26 /pmc/articles/PMC4384282/ /pubmed/25844357 http://dx.doi.org/10.4174/astr.2015.88.4.222 Text en Copyright © 2015, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/3.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Gao, Peng Ji Gao, Jie Li, Zhao Hu, Zhi Ping Zhu, Ji Ye De novo malignancy after liver transplantation: a single-center experience of 14 cases |
title | De novo malignancy after liver transplantation: a single-center experience of 14 cases |
title_full | De novo malignancy after liver transplantation: a single-center experience of 14 cases |
title_fullStr | De novo malignancy after liver transplantation: a single-center experience of 14 cases |
title_full_unstemmed | De novo malignancy after liver transplantation: a single-center experience of 14 cases |
title_short | De novo malignancy after liver transplantation: a single-center experience of 14 cases |
title_sort | de novo malignancy after liver transplantation: a single-center experience of 14 cases |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384282/ https://www.ncbi.nlm.nih.gov/pubmed/25844357 http://dx.doi.org/10.4174/astr.2015.88.4.222 |
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