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Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study

BACKGROUND: Limited therapeutic options are available for patients with treatment-refractory major depression who do not respond to routinely available therapies. Vagus nerve stimulation showed adjunctive antidepressant effect in chronic treatment resistant depression, even though available studies...

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Autores principales: Albert, Umberto, Maina, Giuseppe, Aguglia, Andrea, Vitalucci, Alberto, Bogetto, Filippo, Fronda, Chiara, Ducati, Alessandro, Lanotte, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384299/
https://www.ncbi.nlm.nih.gov/pubmed/25884606
http://dx.doi.org/10.1186/s12888-015-0435-8
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author Albert, Umberto
Maina, Giuseppe
Aguglia, Andrea
Vitalucci, Alberto
Bogetto, Filippo
Fronda, Chiara
Ducati, Alessandro
Lanotte, Michele
author_facet Albert, Umberto
Maina, Giuseppe
Aguglia, Andrea
Vitalucci, Alberto
Bogetto, Filippo
Fronda, Chiara
Ducati, Alessandro
Lanotte, Michele
author_sort Albert, Umberto
collection PubMed
description BACKGROUND: Limited therapeutic options are available for patients with treatment-refractory major depression who do not respond to routinely available therapies. Vagus nerve stimulation showed adjunctive antidepressant effect in chronic treatment resistant depression, even though available studies rarely exceed 2-year follow up. We report a naturalistic 5-year follow up of five patients who received VNS implant for resistant depression (3 patients with major depressive disorder and 2 with bipolar disorder). METHODS: Response was defined as a reduction of the 17-item HDRS total score ≥50% with respect to baseline, remission as a score ≤7. RESULTS: Response and remission rates were both 40% (2/5) after 1 year, and 60% (3/5) at 5 years. Two patients withdrew from the study because of side effects or inefficacy of stimulation. CONCLUSIONS: Our case series showed that long-term VNS may be effective in reducing severity of depression in a small but significant minority of patients, although two patients had stimulation terminated because of adverse effects and/or refusal to continue the study.
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spelling pubmed-43842992015-04-04 Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study Albert, Umberto Maina, Giuseppe Aguglia, Andrea Vitalucci, Alberto Bogetto, Filippo Fronda, Chiara Ducati, Alessandro Lanotte, Michele BMC Psychiatry Research Article BACKGROUND: Limited therapeutic options are available for patients with treatment-refractory major depression who do not respond to routinely available therapies. Vagus nerve stimulation showed adjunctive antidepressant effect in chronic treatment resistant depression, even though available studies rarely exceed 2-year follow up. We report a naturalistic 5-year follow up of five patients who received VNS implant for resistant depression (3 patients with major depressive disorder and 2 with bipolar disorder). METHODS: Response was defined as a reduction of the 17-item HDRS total score ≥50% with respect to baseline, remission as a score ≤7. RESULTS: Response and remission rates were both 40% (2/5) after 1 year, and 60% (3/5) at 5 years. Two patients withdrew from the study because of side effects or inefficacy of stimulation. CONCLUSIONS: Our case series showed that long-term VNS may be effective in reducing severity of depression in a small but significant minority of patients, although two patients had stimulation terminated because of adverse effects and/or refusal to continue the study. BioMed Central 2015-03-31 /pmc/articles/PMC4384299/ /pubmed/25884606 http://dx.doi.org/10.1186/s12888-015-0435-8 Text en © Albert et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Albert, Umberto
Maina, Giuseppe
Aguglia, Andrea
Vitalucci, Alberto
Bogetto, Filippo
Fronda, Chiara
Ducati, Alessandro
Lanotte, Michele
Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
title Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
title_full Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
title_fullStr Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
title_full_unstemmed Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
title_short Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
title_sort vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384299/
https://www.ncbi.nlm.nih.gov/pubmed/25884606
http://dx.doi.org/10.1186/s12888-015-0435-8
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