Cargando…

Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)

BACKGROUND: Risk classification and prediction of prognosis in GIST is still a matter of debate. Data on the impact of age and gender as potential confounding factors are limited. Therefore we comprehensively investigated age and gender as independent risk factors for GIST. METHODS: Two independent...

Descripción completa

Detalles Bibliográficos
Autores principales: Kramer, Klaus, Knippschild, Uwe, Mayer, Benjamin, Bögelspacher, Kira, Spatz, Hanno, Henne-Bruns, Doris, Agaimy, Abbas, Schwab, Matthias, Schmieder, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384379/
https://www.ncbi.nlm.nih.gov/pubmed/25886494
http://dx.doi.org/10.1186/s12885-015-1054-y
_version_ 1782364894358667264
author Kramer, Klaus
Knippschild, Uwe
Mayer, Benjamin
Bögelspacher, Kira
Spatz, Hanno
Henne-Bruns, Doris
Agaimy, Abbas
Schwab, Matthias
Schmieder, Michael
author_facet Kramer, Klaus
Knippschild, Uwe
Mayer, Benjamin
Bögelspacher, Kira
Spatz, Hanno
Henne-Bruns, Doris
Agaimy, Abbas
Schwab, Matthias
Schmieder, Michael
author_sort Kramer, Klaus
collection PubMed
description BACKGROUND: Risk classification and prediction of prognosis in GIST is still a matter of debate. Data on the impact of age and gender as potential confounding factors are limited. Therefore we comprehensively investigated age and gender as independent risk factors for GIST. METHODS: Two independent patient cohorts (cohort I, n = 87 [<50 years]; cohort II, n = 125 [≥50 years]) were extracted from the multicentre Ulmer GIST registry including a total of 659 GIST patients retrospectively collected in 18 collaborative German oncological centers. Based on demographic and clinicopathological parameters and a median follow-up time of 4.3 years (range 0.56; 21.33) disease-specific-survival (DSS), disease-free-survival (DFS) and overall survival (OS) were calculated. RESULTS: GIST patients older than fifty years showed significantly worse DSS compared to younger patients (p = 0.021; HR = 0.307, 95% CI [0.113; 0.834]). DSS was significantly more favorable in younger female GIST patients compared with elderly females (p = 0.008). Female gender resulted again in better prognosis in younger patients (p = 0.033). CONCLUSIONS: Patient age (<50 years) and female gender were significantly associated with a more favourable prognosis in GIST. Extended studies are warranted to confirm our clinical results and to elucidate underlying pathophysiological mechanisms. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-1054-y) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4384379
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-43843792015-04-04 Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST) Kramer, Klaus Knippschild, Uwe Mayer, Benjamin Bögelspacher, Kira Spatz, Hanno Henne-Bruns, Doris Agaimy, Abbas Schwab, Matthias Schmieder, Michael BMC Cancer Research Article BACKGROUND: Risk classification and prediction of prognosis in GIST is still a matter of debate. Data on the impact of age and gender as potential confounding factors are limited. Therefore we comprehensively investigated age and gender as independent risk factors for GIST. METHODS: Two independent patient cohorts (cohort I, n = 87 [<50 years]; cohort II, n = 125 [≥50 years]) were extracted from the multicentre Ulmer GIST registry including a total of 659 GIST patients retrospectively collected in 18 collaborative German oncological centers. Based on demographic and clinicopathological parameters and a median follow-up time of 4.3 years (range 0.56; 21.33) disease-specific-survival (DSS), disease-free-survival (DFS) and overall survival (OS) were calculated. RESULTS: GIST patients older than fifty years showed significantly worse DSS compared to younger patients (p = 0.021; HR = 0.307, 95% CI [0.113; 0.834]). DSS was significantly more favorable in younger female GIST patients compared with elderly females (p = 0.008). Female gender resulted again in better prognosis in younger patients (p = 0.033). CONCLUSIONS: Patient age (<50 years) and female gender were significantly associated with a more favourable prognosis in GIST. Extended studies are warranted to confirm our clinical results and to elucidate underlying pathophysiological mechanisms. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-1054-y) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-14 /pmc/articles/PMC4384379/ /pubmed/25886494 http://dx.doi.org/10.1186/s12885-015-1054-y Text en © Kramer et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kramer, Klaus
Knippschild, Uwe
Mayer, Benjamin
Bögelspacher, Kira
Spatz, Hanno
Henne-Bruns, Doris
Agaimy, Abbas
Schwab, Matthias
Schmieder, Michael
Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)
title Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)
title_full Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)
title_fullStr Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)
title_full_unstemmed Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)
title_short Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)
title_sort impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (gist)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384379/
https://www.ncbi.nlm.nih.gov/pubmed/25886494
http://dx.doi.org/10.1186/s12885-015-1054-y
work_keys_str_mv AT kramerklaus impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT knippschilduwe impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT mayerbenjamin impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT bogelspacherkira impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT spatzhanno impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT hennebrunsdoris impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT agaimyabbas impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT schwabmatthias impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist
AT schmiedermichael impactofageandgenderontumorrelatedprognosisingastrointestinalstromaltumorsgist