Cargando…

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer

INTRODUCTION: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with poor survival in patients with breast cancer by increasing tumor aggressiveness. This work aimed to investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Granados-Principal, Sergio, Liu, Yi, Guevara, Maria L, Blanco, Elvin, Choi, Dong Soon, Qian, Wei, Patel, Tejal, Rodriguez, Angel A, Cusimano, Joseph, Weiss, Heidi L, Zhao, Hong, Landis, Melissa D, Dave, Bhuvanesh, Gross, Steven S, Chang, Jenny C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384389/ https://www.ncbi.nlm.nih.gov/pubmed/25849745 http://dx.doi.org/10.1186/s13058-015-0527-x

Ejemplares similares

Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition
por: Shah, Soham A., et al.
Publicado: (2023)

The dual role of iNOS in cancer()
por: Vannini, Federica, et al.
Publicado: (2015)

Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock
por: Schweighöfer, Hanna, et al.
Publicado: (2014)

Clinical Implications of iNOS Levels in Triple-Negative Breast Cancer Responding to Neoadjuvant Chemotherapy
por: Jin, Zining, et al.
Publicado: (2015)

Aging and Insulin Resistance: Just Say iNOS
por: Evans, Joseph L., et al.
Publicado: (2013)

The expressions of AMACR and iNOS in prostate adenocarcinomas
por: Ozgur, Tumay, et al.
Publicado: (2013)

Targeting iNOS to increase efficacy of immunotherapies
por: Ekmekcioglu, Suhendan, et al.
Publicado: (2017)

eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia
por: Du, L, et al.
Publicado: (2017)

Upregulation of iNOS and phosphorylated eNOS in the implantation‐induced blastocysts of mice
por: Seki, Misato, et al.
Publicado: (2023)

iNOS polymorphism modulates iNOS/NO expression via impaired antioxidant and ROS content in P. vivax and P. falciparum infection
por: Kumar, Amod, et al.
Publicado: (2017)

HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway
por: Liu, Yi, et al.
Publicado: (2017)

Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity
por: Torrisi, Jeremy S., et al.
Publicado: (2016)

Recipient iNOS but Not eNOS Deficiency Reduces Luminal Narrowing in Tracheal Allografts
por: Minamoto, Kanji, et al.
Publicado: (2002)

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS
por: Morsy, Mohamed A., et al.
Publicado: (2014)

The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS
por: Wheatley, Carmen
Publicado: (2007)

Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo
por: Bucci, Mariarosaria, et al.
Publicado: (2013)

The role of tumour-derived iNOS in tumour progression and angiogenesis
por: Kostourou, V, et al.
Publicado: (2011)

Regulation of iNOS on Immune Cells and Its Role in Diseases
por: Xue, Qingjie, et al.
Publicado: (2018)

Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity
por: Qian, Qingwen, et al.
Publicado: (2019)

The Potential Role of iNOS in Ovarian Cancer Progression and Chemoresistance
por: Kielbik, Michal, et al.
Publicado: (2019)

Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO
por: Kashfi, Khosrow, et al.
Publicado: (2021)

mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour
por: Törnblom, Susanne Abelin, et al.
Publicado: (2005)

Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and cachexia
por: Hall, Derek T., et al.
Publicado: (2011)

The Circadian Deadenylase Nocturnin Is Necessary for Stabilization of the iNOS mRNA in Mice
por: Niu, Shuang, et al.
Publicado: (2011)

Retraction: Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo
Publicado: (2019)

Characterization of iNOS(+) Neutrophil-like ring cell in tumor-bearing mice
por: Virtuoso, Lauren P, et al.
Publicado: (2012)

Obesity, Inflammation, and Exercise Training: Relative Contribution of iNOS and eNOS in the Modulation of Vascular Function in the Mouse Aorta
por: Silva, Josiane F., et al.
Publicado: (2016)

Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
por: Chu, Guo-Hua, et al.
Publicado: (2009)

iNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis
por: Wang, Jun, et al.
Publicado: (2015)

iNOS is associated with tumorigenicity as an independent prognosticator in human intrahepatic cholangiocarcinoma
por: Liu, Sulai, et al.
Publicado: (2019)

Therapeutic effects of iNOS inhibition against vitiligo in an animal model
por: Mansourpour, Hamid, et al.
Publicado: (2019)

Evaluation of the Potential Association between NOS Gene Polymorphisms (iNOS G-954C and eNOS G894T) and Psoriasis
por: Duan, Xi, et al.
Publicado: (2016)

Insights into human eNOS, nNOS and iNOS structures and medicinal indications from statistical analyses of their interactions with bound compounds
por: Dong, Jianshu, et al.
Publicado: (2023)

The genetic association between iNOS and eNOS polymorphisms and gastric cancer risk: a meta-analysis
por: Zhu, Yi, et al.
Publicado: (2018)

Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems
por: Guimarães, Lara M.F., et al.
Publicado: (2021)

Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner
por: Simovic Markovic, Bojana, et al.
Publicado: (2017)

Expression of Inducible Nitric Oxide Synthase (iNOS) in Microglia of the Developing Quail Retina
por: Sierra, Ana, et al.
Publicado: (2014)

Effect of iNOS inhibition on exhaled NO and serum nitrate in hyperdynamic porcine endotoxemia
por: Theisen, MM, et al.
Publicado: (2000)

Zinc regulates iNOS-derived nitric oxide formation in endothelial cells
por: Cortese-Krott, Miriam M., et al.
Publicado: (2014)

Effects of ghrelin on protein expression of antioxidative enzymes and iNOS in the rat liver
por: Dobutovic, Branislava, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0bbojb3a112nfug6o7tgi70tb0