The importance of loop length on the stability of i-motif structures

Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

Detalles Bibliográficos
Autores principales: Gurung, Sarah P., Schwarz, Christine, Hall, James P., Cardin, Christine J., Brazier, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384421/
https://www.ncbi.nlm.nih.gov/pubmed/25686374
http://dx.doi.org/10.1039/c4cc07279k
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author Gurung, Sarah P.
Schwarz, Christine
Hall, James P.
Cardin, Christine J.
Brazier, John A.
author_facet Gurung, Sarah P.
Schwarz, Christine
Hall, James P.
Cardin, Christine J.
Brazier, John A.
author_sort Gurung, Sarah P.
collection PubMed
description Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.
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spelling pubmed-43844212015-04-08 The importance of loop length on the stability of i-motif structures Gurung, Sarah P. Schwarz, Christine Hall, James P. Cardin, Christine J. Brazier, John A. Chem Commun (Camb) Chemistry Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability. Royal Society of Chemistry 2015-04-04 2015-02-16 /pmc/articles/PMC4384421/ /pubmed/25686374 http://dx.doi.org/10.1039/c4cc07279k Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Gurung, Sarah P.
Schwarz, Christine
Hall, James P.
Cardin, Christine J.
Brazier, John A.
The importance of loop length on the stability of i-motif structures
title The importance of loop length on the stability of i-motif structures
title_full The importance of loop length on the stability of i-motif structures
title_fullStr The importance of loop length on the stability of i-motif structures
title_full_unstemmed The importance of loop length on the stability of i-motif structures
title_short The importance of loop length on the stability of i-motif structures
title_sort importance of loop length on the stability of i-motif structures
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384421/
https://www.ncbi.nlm.nih.gov/pubmed/25686374
http://dx.doi.org/10.1039/c4cc07279k
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