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Crystal structure of a mixed solvated form of amoxapine acetate

The mixed solvated salt 4-(2-chloro­dibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate–acetic acid–cyclo­hexane (2/2/1), C(17)H(17)ClN(3)O(+)·C(2)H(3)O(2) (−)·C(2)H(4)O(2)·0.5C(6)H(12), crystallizes with one mol­ecule of protonated amoxapine (AXPN), an acetate anion and a mol­ecule of acetic ac...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Rajni M., Raval, Vishal, Oswald, Iain D. H., Florence, Alastair J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384552/
https://www.ncbi.nlm.nih.gov/pubmed/25878802
http://dx.doi.org/10.1107/S2056989014028096
Descripción
Sumario:The mixed solvated salt 4-(2-chloro­dibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate–acetic acid–cyclo­hexane (2/2/1), C(17)H(17)ClN(3)O(+)·C(2)H(3)O(2) (−)·C(2)H(4)O(2)·0.5C(6)H(12), crystallizes with one mol­ecule of protonated amoxapine (AXPN), an acetate anion and a mol­ecule of acetic acid together with half a mol­ecule of cyclo­hexane. In the centrosymmetric crystal, both enanti­omers of the protonated AXPN mol­ecule stack alternatively along [001]. Acetate anions connect the AXPN cations through N—H⋯O hydrogen bonding in the [010] direction, creating a sheet lying parallel to (100). The acetic acid mol­ecules are linked to the acetate anions via O—H⋯O hydrogen bonds within the sheets. Within the sheets there are also a number of C—H⋯O hydrogen bonds present. The cyclo­hexane solvent mol­ecules occupy the space between the sheets.