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Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function. We present crystallographic and biochemical analyses of Btk, which together reveal molecular details of its autoinhibition and activation. Autoinhibited Btk adopts a compact conformation like that of...

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Detalles Bibliográficos
Autores principales:	Wang, Qi, Vogan, Erik M, Nocka, Laura M, Rosen, Connor E, Zorn, Julie A, Harrison, Stephen C, Kuriyan, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384635/ https://www.ncbi.nlm.nih.gov/pubmed/25699547 http://dx.doi.org/10.7554/eLife.06074

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