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Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia
Mutations in genes essential for protein homeostasis have been identified in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Why mature neurons should be particularly sensitive to such perturbations is unclear. We identified mutations in Rab8 in a genetic screen for e...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384727/ https://www.ncbi.nlm.nih.gov/pubmed/25800055 http://dx.doi.org/10.1083/jcb.201404066 |