CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation

Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the brain and are strongly associated with hemorrhagic stroke, seizures, and other neurological disorders. CCM2 binds CCM3, but the molecular basis...

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Detalles Bibliográficos
Autores principales: Draheim, Kyle M., Li, Xiaofeng, Zhang, Rong, Fisher, Oriana S., Villari, Giulia, Boggon, Titus J., Calderwood, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384732/
https://www.ncbi.nlm.nih.gov/pubmed/25825518
http://dx.doi.org/10.1083/jcb.201407129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384732/
https://www.ncbi.nlm.nih.gov/pubmed/25825518
http://dx.doi.org/10.1083/jcb.201407129

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