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Impaired allocentric spatial processing in posttraumatic stress disorder

A neurobiological dual representation model of PTSD proposes that reduced hippocampus-dependent contextual processing contributes to intrusive imagery due to a loss of control over hippocampus-independent sensory and affective representations. We investigated whether PTSD sufferers show impaired all...

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Autores principales: Smith, Kirsten V., Burgess, Neil, Brewin, Chris R., King, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384783/
https://www.ncbi.nlm.nih.gov/pubmed/25636201
http://dx.doi.org/10.1016/j.nlm.2015.01.007
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author Smith, Kirsten V.
Burgess, Neil
Brewin, Chris R.
King, John A.
author_facet Smith, Kirsten V.
Burgess, Neil
Brewin, Chris R.
King, John A.
author_sort Smith, Kirsten V.
collection PubMed
description A neurobiological dual representation model of PTSD proposes that reduced hippocampus-dependent contextual processing contributes to intrusive imagery due to a loss of control over hippocampus-independent sensory and affective representations. We investigated whether PTSD sufferers show impaired allocentric spatial processing indicative of reduced hippocampal functioning. Trauma-exposed individuals with (N = 29) and without (N = 30) a diagnosis of PTSD completed two tests of spatial processing: a topographical recognition task comprising perceptual and memory components, and a test of memory for objects’ locations within a virtual environment in which the test is from either the same viewpoint as presentation (solvable with egocentric memory) or a different viewpoint (requiring allocentric memory). Participants in the PTSD group performed significantly worse on allocentric spatial processing than trauma-exposed controls. Groups performed comparably on egocentric memory and non-spatial memory for lists of objects. Exposure to repeated incident trauma was also associated with significantly worse spatial processing in the PTSD group. Results show a selective impairment in allocentric spatial processing, implicating weak hippocampal functioning, as predicted by a neurobiological dual representation model of PTSD. These findings have important clinical implications for cognitive therapy.
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spelling pubmed-43847832015-04-07 Impaired allocentric spatial processing in posttraumatic stress disorder Smith, Kirsten V. Burgess, Neil Brewin, Chris R. King, John A. Neurobiol Learn Mem Article A neurobiological dual representation model of PTSD proposes that reduced hippocampus-dependent contextual processing contributes to intrusive imagery due to a loss of control over hippocampus-independent sensory and affective representations. We investigated whether PTSD sufferers show impaired allocentric spatial processing indicative of reduced hippocampal functioning. Trauma-exposed individuals with (N = 29) and without (N = 30) a diagnosis of PTSD completed two tests of spatial processing: a topographical recognition task comprising perceptual and memory components, and a test of memory for objects’ locations within a virtual environment in which the test is from either the same viewpoint as presentation (solvable with egocentric memory) or a different viewpoint (requiring allocentric memory). Participants in the PTSD group performed significantly worse on allocentric spatial processing than trauma-exposed controls. Groups performed comparably on egocentric memory and non-spatial memory for lists of objects. Exposure to repeated incident trauma was also associated with significantly worse spatial processing in the PTSD group. Results show a selective impairment in allocentric spatial processing, implicating weak hippocampal functioning, as predicted by a neurobiological dual representation model of PTSD. These findings have important clinical implications for cognitive therapy. Academic Press 2015-03 /pmc/articles/PMC4384783/ /pubmed/25636201 http://dx.doi.org/10.1016/j.nlm.2015.01.007 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Smith, Kirsten V.
Burgess, Neil
Brewin, Chris R.
King, John A.
Impaired allocentric spatial processing in posttraumatic stress disorder
title Impaired allocentric spatial processing in posttraumatic stress disorder
title_full Impaired allocentric spatial processing in posttraumatic stress disorder
title_fullStr Impaired allocentric spatial processing in posttraumatic stress disorder
title_full_unstemmed Impaired allocentric spatial processing in posttraumatic stress disorder
title_short Impaired allocentric spatial processing in posttraumatic stress disorder
title_sort impaired allocentric spatial processing in posttraumatic stress disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384783/
https://www.ncbi.nlm.nih.gov/pubmed/25636201
http://dx.doi.org/10.1016/j.nlm.2015.01.007
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