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Impaired allocentric spatial processing in posttraumatic stress disorder
A neurobiological dual representation model of PTSD proposes that reduced hippocampus-dependent contextual processing contributes to intrusive imagery due to a loss of control over hippocampus-independent sensory and affective representations. We investigated whether PTSD sufferers show impaired all...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384783/ https://www.ncbi.nlm.nih.gov/pubmed/25636201 http://dx.doi.org/10.1016/j.nlm.2015.01.007 |
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author | Smith, Kirsten V. Burgess, Neil Brewin, Chris R. King, John A. |
author_facet | Smith, Kirsten V. Burgess, Neil Brewin, Chris R. King, John A. |
author_sort | Smith, Kirsten V. |
collection | PubMed |
description | A neurobiological dual representation model of PTSD proposes that reduced hippocampus-dependent contextual processing contributes to intrusive imagery due to a loss of control over hippocampus-independent sensory and affective representations. We investigated whether PTSD sufferers show impaired allocentric spatial processing indicative of reduced hippocampal functioning. Trauma-exposed individuals with (N = 29) and without (N = 30) a diagnosis of PTSD completed two tests of spatial processing: a topographical recognition task comprising perceptual and memory components, and a test of memory for objects’ locations within a virtual environment in which the test is from either the same viewpoint as presentation (solvable with egocentric memory) or a different viewpoint (requiring allocentric memory). Participants in the PTSD group performed significantly worse on allocentric spatial processing than trauma-exposed controls. Groups performed comparably on egocentric memory and non-spatial memory for lists of objects. Exposure to repeated incident trauma was also associated with significantly worse spatial processing in the PTSD group. Results show a selective impairment in allocentric spatial processing, implicating weak hippocampal functioning, as predicted by a neurobiological dual representation model of PTSD. These findings have important clinical implications for cognitive therapy. |
format | Online Article Text |
id | pubmed-4384783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43847832015-04-07 Impaired allocentric spatial processing in posttraumatic stress disorder Smith, Kirsten V. Burgess, Neil Brewin, Chris R. King, John A. Neurobiol Learn Mem Article A neurobiological dual representation model of PTSD proposes that reduced hippocampus-dependent contextual processing contributes to intrusive imagery due to a loss of control over hippocampus-independent sensory and affective representations. We investigated whether PTSD sufferers show impaired allocentric spatial processing indicative of reduced hippocampal functioning. Trauma-exposed individuals with (N = 29) and without (N = 30) a diagnosis of PTSD completed two tests of spatial processing: a topographical recognition task comprising perceptual and memory components, and a test of memory for objects’ locations within a virtual environment in which the test is from either the same viewpoint as presentation (solvable with egocentric memory) or a different viewpoint (requiring allocentric memory). Participants in the PTSD group performed significantly worse on allocentric spatial processing than trauma-exposed controls. Groups performed comparably on egocentric memory and non-spatial memory for lists of objects. Exposure to repeated incident trauma was also associated with significantly worse spatial processing in the PTSD group. Results show a selective impairment in allocentric spatial processing, implicating weak hippocampal functioning, as predicted by a neurobiological dual representation model of PTSD. These findings have important clinical implications for cognitive therapy. Academic Press 2015-03 /pmc/articles/PMC4384783/ /pubmed/25636201 http://dx.doi.org/10.1016/j.nlm.2015.01.007 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Smith, Kirsten V. Burgess, Neil Brewin, Chris R. King, John A. Impaired allocentric spatial processing in posttraumatic stress disorder |
title | Impaired allocentric spatial processing in posttraumatic stress disorder |
title_full | Impaired allocentric spatial processing in posttraumatic stress disorder |
title_fullStr | Impaired allocentric spatial processing in posttraumatic stress disorder |
title_full_unstemmed | Impaired allocentric spatial processing in posttraumatic stress disorder |
title_short | Impaired allocentric spatial processing in posttraumatic stress disorder |
title_sort | impaired allocentric spatial processing in posttraumatic stress disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384783/ https://www.ncbi.nlm.nih.gov/pubmed/25636201 http://dx.doi.org/10.1016/j.nlm.2015.01.007 |
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