Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility

Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe(3)O(4) nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoli, Zhang, Huan, Chang, Le, Yu, Baozhi, Liu, Qiuying, Wu, Jianpeng, Miao, Yuqing, Ma, Pei, Fan, Daidi, Fan, Haiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384969/
https://www.ncbi.nlm.nih.gov/pubmed/25852325
http://dx.doi.org/10.1186/s11671-015-0752-3
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author Liu, Xiaoli
Zhang, Huan
Chang, Le
Yu, Baozhi
Liu, Qiuying
Wu, Jianpeng
Miao, Yuqing
Ma, Pei
Fan, Daidi
Fan, Haiming
author_facet Liu, Xiaoli
Zhang, Huan
Chang, Le
Yu, Baozhi
Liu, Qiuying
Wu, Jianpeng
Miao, Yuqing
Ma, Pei
Fan, Daidi
Fan, Haiming
author_sort Liu, Xiaoli
collection PubMed
description Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe(3)O(4) nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe(3)O(4) nanoparticles before coating with HLC, HLC-coated Fe(3)O(4) nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe(3)O(4) nanoparticles has improved biocompatibility. Our results clearly show that Fe(3)O(4) nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.
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spelling pubmed-43849692015-04-07 Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility Liu, Xiaoli Zhang, Huan Chang, Le Yu, Baozhi Liu, Qiuying Wu, Jianpeng Miao, Yuqing Ma, Pei Fan, Daidi Fan, Haiming Nanoscale Res Lett Nano Express Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe(3)O(4) nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe(3)O(4) nanoparticles before coating with HLC, HLC-coated Fe(3)O(4) nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe(3)O(4) nanoparticles has improved biocompatibility. Our results clearly show that Fe(3)O(4) nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications. Springer US 2015-01-31 /pmc/articles/PMC4384969/ /pubmed/25852325 http://dx.doi.org/10.1186/s11671-015-0752-3 Text en © Liu et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Nano Express
Liu, Xiaoli
Zhang, Huan
Chang, Le
Yu, Baozhi
Liu, Qiuying
Wu, Jianpeng
Miao, Yuqing
Ma, Pei
Fan, Daidi
Fan, Haiming
Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility
title Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility
title_full Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility
title_fullStr Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility
title_full_unstemmed Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility
title_short Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility
title_sort human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384969/
https://www.ncbi.nlm.nih.gov/pubmed/25852325
http://dx.doi.org/10.1186/s11671-015-0752-3
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