The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

BACKGROUND: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabell...

Descripción completa

Detalles Bibliográficos
Autores principales: van Uhm, Janneke IM, Visser, Gerard WM, van der Schans, Marcel J, Geldof, Albert A, Meuleman, Eric JH, Nieuwenhuijzen, Jakko A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385017/
https://www.ncbi.nlm.nih.gov/pubmed/25853011
http://dx.doi.org/10.1186/s13550-015-0083-5

Ejemplares similares

Ejemplares similares