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EMT and tumor metastasis
EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385028/ https://www.ncbi.nlm.nih.gov/pubmed/25852822 http://dx.doi.org/10.1186/s40169-015-0048-3 |
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author | Heerboth, Sarah Housman, Genevieve Leary, Meghan Longacre, Mckenna Byler, Shannon Lapinska, Karolina Willbanks, Amber Sarkar, Sibaji |
author_facet | Heerboth, Sarah Housman, Genevieve Leary, Meghan Longacre, Mckenna Byler, Shannon Lapinska, Karolina Willbanks, Amber Sarkar, Sibaji |
author_sort | Heerboth, Sarah |
collection | PubMed |
description | EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several types of tumors, and lastly, we discuss the role of epigenetic events that regulate EMT/MET processes. We hypothesize that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers. |
format | Online Article Text |
id | pubmed-4385028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-43850282015-04-07 EMT and tumor metastasis Heerboth, Sarah Housman, Genevieve Leary, Meghan Longacre, Mckenna Byler, Shannon Lapinska, Karolina Willbanks, Amber Sarkar, Sibaji Clin Transl Med Review EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several types of tumors, and lastly, we discuss the role of epigenetic events that regulate EMT/MET processes. We hypothesize that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers. Springer Berlin Heidelberg 2015-02-26 /pmc/articles/PMC4385028/ /pubmed/25852822 http://dx.doi.org/10.1186/s40169-015-0048-3 Text en © Heerboth et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Heerboth, Sarah Housman, Genevieve Leary, Meghan Longacre, Mckenna Byler, Shannon Lapinska, Karolina Willbanks, Amber Sarkar, Sibaji EMT and tumor metastasis |
title | EMT and tumor metastasis |
title_full | EMT and tumor metastasis |
title_fullStr | EMT and tumor metastasis |
title_full_unstemmed | EMT and tumor metastasis |
title_short | EMT and tumor metastasis |
title_sort | emt and tumor metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385028/ https://www.ncbi.nlm.nih.gov/pubmed/25852822 http://dx.doi.org/10.1186/s40169-015-0048-3 |
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